Level of maternal respiratory syncytial virus (RSV) F antibodies in hospitalized children and correlates of protection

Sara A. Taleb
Khalid Al-Ansari
Gheyath K. Nasrallah
Mohamed A. Elrayess
Asmaa A. Al-Thani
Alexandrine Derrien-Colemyn
Tracy J. Ruckwardt
Barney S. Graham
Hadi M. Yassine

Open link

Publication date

August 2021

DOI

10.1016/j.ijid.2021.06.015

Publisher

Elsevier BV

Journal

International Journal of Infectious Diseases

Abstract

Background: Respiratory syncytial virus (RSV) is a major cause of lower respiratory infection among children and no vaccine is available. The stabilized form of the fusion (F) protein – pre-F – is a leading vaccine candidate to target different populations, including pregnant women. This study aimed to determine the magnitude and nature of RSV-directed maternal antibodies (matAbs) in hospitalized children with RSV infection. Methods: Sixty-five paired blood samples were collected from RSV-infected children aged <6 months and their corresponding mothers. All pairs were screened for levels of pre-F and post-F antibodies using ELISA. The neutralizing antibodies (NAbs) in both groups were measured in vitro against mKate RSV-A2 using H28 cells. ...