Insulin-independent Hypoglycemic Effects of Combined Hydroalcoholic Extract of Medicinal Plants CapparisspinosaRoot, Nerium oleander Leaf, Aloe veraGel, Daucuscarota Seed and ApiumgraveolensSeed in Normal and Streptozotocin-induced Diabetic Rats

Background and Objectives:Use of non-chemical treatments (medicinal plants) is a novel approach in the treatment of diabetes.This study was conducted with the aim of determining the effect of combined hydroalcoholicextract of medicinal plants on the treatment of diabetes in normal and diabetic male rats and its comparison with the effect of glibenclamide. Methods:Thirty-six male rats were randomly divided into six groups: normal control (NC), diabetic control (DC), diabetic rats received the plant extract at a dose of 0.2g/Kg (D0.2) and 0.4g/kg (D0.4), and normal rats received 0.2g/kg plant extract (N0.2). The induction of diabetes was performed by intraperitonealinjection of a single dose of 60mg/kg of streptozotocin. Glucose level and weight were measured after injection of streptozotocinand 4-week gavage, and the insulin level was measured only at the end of the 5th week. Data were analyzed using one-way ANOVA and Tukey’s test. The significance level was considered to be p<0.05. Results: The blood glucose level in D0.2 group was significantly decreased (p0.05 DC vs. D0.4, D0.2), but in DG group, a significant increase (p