Chitosan nanoparticles enhance the antibacterial activity of the native polymer against bovine mastitis pathogens
- Orellano, María Soledad
- Isaac, Paula
- Breser, Maria Laura
- Bohl, Luciana Paola
- Conesa, Agustin
- Falcone, Ruben Dario
- Porporatto, Carina
DOIAbstract
Staphylococcus is the most commonly isolated genus from animals with intramammary infections, and mastitis is the most prevalent disease that affects dairy cows in many countries. These pathogens can live in biofilms, a self-produced matrix, which allow them evade the innate immune system and the antibiotic therapy, thereby producing persistent infections. The aim of this study was to explore the antimicrobial potential of chitosan nanoparticles (Ch-NPs) obtained by the reverse micellar method. We found that the nanoformulation developed presents antimicrobial activity against mastitis pathogens in a dose-dependent manner. Moreover, different experiments corroborated that the antimicrobial effectiveness of Ch-NP was greater than that shown ...
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