The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population

Background: Inherited and environmental factors are implicated in the expression of porphyria cutanea tarda (PCT); the contribution of each factor depends on the population.Inherited and environmental factors are implicated in the expression of porphyria cutanea tarda (PCT); the contribution of each factor depends on the population. Objective: To provide a review of PCT cases diagnosed in Argentina over 24 years and evaluate the role of different precipitating factors in its pathogenesis.To provide a review of PCT cases diagnosed in Argentina over 24 years and evaluate the role of different precipitating factors in its pathogenesis. Methods: Plasma and urinary porphyrin levels and erythrocyte uroporphyrinogen decarboxylase (URO-D) activity were determined. Potential precipitating factors were identified in each patient. Additional tests for hepatitis C virus (HCV) and hemochromatosis gene mutations were carried out.Plasma and urinary porphyrin levels and erythrocyte uroporphyrinogen decarboxylase (URO-D) activity were determined. Potential precipitating factors were identified in each patient. Additional tests for hepatitis C virus (HCV) and hemochromatosis gene mutations were carried out. Results: Several factors (mainly alcohol abuse in men and estrogen ingestion in women), alone or combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) Several factors (mainly alcohol abuse in men and estrogen ingestion in women), alone or combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.)Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.)Fil: Méndez, Manuel. Universidad de Buenos Aires; ArgentinaFil: Rossetti, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; ArgentinaFil: Batlle, Alcira María del C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; ArgentinaFil: Parera, Victoria Estela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; Argentin