Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces
- Perez Enriquez, Darlin Johana
- Dell'arciprete, Maria Laura
- Dittler, Maria Laura
- Miñan, Alejandro Guillermo
- Prieto, Eduardo Daniel
- Gonzalez, Monica Cristina
DOIAbstract
A highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca2+ modified mica surface, hydroxyapatite nanoparticle (Ap) films on glass, and Ap modified 45S5® bioactive glass-based scaffolds) with the consequent disruption of the inorganic structure and release of (bio) molecules contained in the interior. The antibiotic Levofloxacin (LX) was used as a model drug for encapsulation and drug release studies which allowed monitoring by fluorescence spectroscopic methods. The accumulation and disruption of CaP nanoshells triggered by ...
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