The effect of ibrutinib on neutrophil and γδ T cell functions
- Risnik, Denise Mariel
- Elías, Esteban Enrique
- Keitelman, Irene Angélica
- Colado, Ana
- Podaza, Enrique Arturo
- Cordini, Gregorio
- Vergara Rubio, Maricef
- Fernández Grecco, Horacio
- Bezares, Raimundo Fernando
- Borge, Mercedes
- Trevani, Analía Silvina
- Giordano, Mirta Nilda
- Jancic, Carolina Cristina
- Gamberale, Romina
DOIAbstract
Ibrutinib is a BTK/ITK inhibitor with efficacy for the treatment of various lymphoid cancers, including CLL. Considering that innate and adaptative immune defects are a dominant feature of CLL patients, we evaluated whether in vitro ibrutinib affects the survival and function of neutrophils and cd T cells, key players of the early immune response against microbes. Neutrophils and cd T cells were obtained from peripheral blood of healthy donors and CLL patients. We found that ibrutinib reduces the production of reactive oxygen species (ROS) and bacteria killing capacity, and slightly impairs neutrophil extracellular traps (NETs) production without affecting bacteria-uptake and CD62L-downregulation induced by fMLP or aggregated IgG. In additi...
Add to ORKG