The phthalate DEHP modulates the estrogen receptors α and β increasing lactotroph cell population in female pituitary glands
- Pérez, Pablo Aníbal
- Toledo, Jonathan
- Sosa, Liliana del Valle
- Peinetti, Nahuel
- Torres, Alicia Ines
- de Paul, Ana Lucia
- Gutiérrez, Silvina
DOIAbstract
Humans are exposed to numerous endocrine disruptors on a daily basis, which may interfere with endogenous estrogens, with Di-(2-ethylhexyl) phthalate (DEHP) being one of the most employed. The anterior pituitary gland is a target of 17β-estradiol (E2) through the specific estrogen receptors (ERs) α and β, whose expression levels fluctuate in the gland under different contexts, and the ERα/β index is responsible for the final E2 effect. The aim of the present study was to evaluate in vivo and in vitro the DEHP effects on ERα and β expression in the pituitary cell population, and also its impact on lactotroph and somatotroph cell growth. Our results revealed that perinatal exposure to DEHP altered the ERα and β expression pattern in pituitary...
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