Self-collected saliva for SARS-CoV-2 detection: A prospective study in the emergency room
- Echavarría, Marcela Silvia
- Reyes, Noelia Soledad
- Rodriguez, Pamela Elizabeth
- Ypas, Martin
- Ricarte, Joaquina Carmen
- Rodriguez, María P.
- Pérez, Matías Gastón
- Seoane, Alejandro
- Martinez, Alfredo
- Videla, Cristina Mónica
- Stryjewski, Martin E.
- Carballal, Guadalupe
DOIAbstract
Current diagnostic standards involve severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection in nasopharyngeal swabs (NPS), but saliva is an attractive and noninvasive option for diagnosis. The objectives were to determine the performance of saliva in comparison with NPS for detecting SARS-CoV-2 and to compare the optimized home brew reverse-transcription polymerase chain reaction (RT-PCR) with a commercial RT-PCR. Paired NPS and saliva specimens were prospectively collected and tested by RT-PCR from patients presenting at an emergency room with signs and symptoms compatible with coronavirus disease-2019. A total of 348 samples from 174 patients were tested by RT-PCR assays. Among 174 patients with symptoms, 63 (36%) were SAR...
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