Blood neutrophils from children with COVID-19 exhibit both inflammatory and anti-inflammatory markers
- Seery, Vanesa
- Raiden, Silvina Claudia
- Algieri, Silvia C.
- Grisolía, Nicolás A.
- Filippo, Daniela
- De Carli, Norberto
- Di Lalla, Sandra
- Cairoli, Héctor
- Chiolo, María J.
- Meregalli, Claudia N.
- Gimenez, Lorena I.
- Gregorio, Gabriela
- Sarli, Mariam
- Alcalde, Ana L.
- Davenport, Carolina
- Bruera, María J.
- Simaz, Nancy
- Pérez, Mariela F.
- Nivela, Valeria
- Bayle, Carola
- Tuccillo, Patricia
- Agosta, María T.
- Pérez, Hernán
- Villa Nova, Susana
- Suárez, Patricia
- Takata, Eugenia M.
- García, Mariela
- Lattner, Jorge
- Rolón, María J.
- Coll, Patricia
- Sananez, Inés
- Holgado, María Pía
- Ferrero, Fernando
- Geffner, Jorge Raúl
- Arruvito, Maria Lourdes
DOIAbstract
Background: Perhaps reflecting that children with COVID-19 rarely exhibit severe respiratory symptoms and often remain asymptomatic, little attention has been paid to explore the immune response in pediatric COVID-19. Here, we analyzed the phenotype and function of circulating neutrophils from children with COVID-19. Methods: An observational study including 182 children with COVID-19, 21 children with multisystem inflammatory syndrome (MIS-C), and 40 healthy children was performed in Buenos Aires, Argentina. Neutrophil phenotype was analyzed by flow cytometry in blood samples. Cytokine production, plasma levels of IgG antibodies directed to the spike protein of SARS-CoV-2 and citrullinated histone H3 were measured by ELISA. Cell-free DNA w...
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