Comparative skin penetration profiles of formulations including ultradeformable liposomes as potential nanocosmeceutical carriers
- Izquierdo, María Cecilia
- Lillo, Rolando Cristian Rodrigo
- Bucci, Paula Lorena
- Gomez, Gisela Eliane
- Martínez, Luis
- Alonso, Silvia del Valle
- Calienni, Maria Natalia
- Martinetti Montanari, Jorge Anibal
DOIAbstract
Background: Ultradeformable liposomes are promising carriers for cosmeceutical actives as they can be loaded with molecules of different polarities, and they present unique penetration properties. Aims: While those features have already been tested, we wanted to know whether their special penetration properties could be maintained after incorporation in diverse cosmetic vehicles, including commercial products already in the market. Methods: Ultradeformable liposomes loaded with a lipophilic and a hydrophilic fluorescent probe were prepared by lipid film resuspension, followed by extrusion and incorporation to different vehicles and commercial products. Penetration was determined in human and pig skin by incubation, with the Saarbrücken pene...
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