Characterization of a neutralizing anti-human galectin-1 monoclonal antibody with angioregulatory and immunomodulatory activities
- Pérez Sáez, Juan Manuel
- Hockl, Pablo Francisco
- Cagnoni, Alejandro
- Mendez Huergo, Santiago Patricio
- García, Pablo Alfredo
- Gatto, Sabrina Gisela
- Cerliani, Juan Pablo
- Croci Russo, Diego Omar
- Rabinovich, Gabriel Adrián
DOIAbstract
Galectins, a family of highly conserved β-galactoside-binding proteins, control tumor progression by modulating different hallmarks of cancer. Galectin-1 (Gal-1), a proto-type member of this family, plays essential roles in tumor angiogenesis and immunosuppression by cross-linking glycosylated receptors on the surface of endothelial and immune cells. Targeted disruption of Gal-1 suppresses tumor growth by counteracting aberrant angiogenesis and reinforcing antitumor immunity in several experimental settings. Given the multiple therapeutic benefits associated with Gal-1 blockade, several Gal-1 inhibitors, including glycan-based competitors, antagonistic peptides, aptamers and neutralizing monoclonal antibodies, have been designed and evaluat...
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