Oxidative post-translational modification of proteins by molecular oxygen (O2)- and nitric oxide (•NO)-derived reactive species is a usual process that occurs in mammalian tissues under both physiological and pathological conditions and can exert either regulatory or cytotoxic effects. Although the side chain of several amino acids is prone to experience oxidative modifications, tyrosine residues are one of the preferred targets of one-electron oxidants, given the ability of their phenolic side chain to undergo reversible one-electron oxidation to the relatively stable tyrosyl radical. Naturally occurring as reversible catalytic intermediates at the active site of a variety of enzymes, tyrosyl radicals can also lead to the formation of seve...
Protein post-translational modifications are of great interest due to their effects on protein struc...
The physiologically important free radicals, nitrogen monoxide and superoxide, can combine to form t...
Nitric oxide (·NO) is a diffusible messenger implicated in Trypanosoma cruzi resistance. Excess prod...
Posttranslational modifications of proteins play key roles in the regulation of biological processes...
3-nitrotyrosine is a post-translational modification on tyrosine residues detected under a range ofp...
AbstractPeroxynitrite (ONOO−) is a `reactive nitrogen species' that can be formed (among other react...
The significance of NO2Tyr in vivo is highlighted by observations that nitrated proteins are markedl...
Background: Reactive oxygen (ROS), and nitrogen (RNS) species are formed during normal metabolism an...
Protein tyrosine nitration (PTN) is a post-translational modification occurring under the action of ...
Tyrosine nitration is an oxidative post-translational protein modification relevant to various patho...
Protein tyrosine nitration (PTN) is a post-translational modification occurring under the action of ...
Protein 3-nitrotyrosine is a post-translational modification that commonly arises from the nitration...
Protein oxidation is increasingly recognised as an important modulator of biochemical pathways contr...
Protein tyrosine nitration (PTN) is a post-translational modification occurring under the action of ...
AbstractProteins are targets of reactive species and detection of oxidatively modified proteins is o...
Protein post-translational modifications are of great interest due to their effects on protein struc...
The physiologically important free radicals, nitrogen monoxide and superoxide, can combine to form t...
Nitric oxide (·NO) is a diffusible messenger implicated in Trypanosoma cruzi resistance. Excess prod...
Posttranslational modifications of proteins play key roles in the regulation of biological processes...
3-nitrotyrosine is a post-translational modification on tyrosine residues detected under a range ofp...
AbstractPeroxynitrite (ONOO−) is a `reactive nitrogen species' that can be formed (among other react...
The significance of NO2Tyr in vivo is highlighted by observations that nitrated proteins are markedl...
Background: Reactive oxygen (ROS), and nitrogen (RNS) species are formed during normal metabolism an...
Protein tyrosine nitration (PTN) is a post-translational modification occurring under the action of ...
Tyrosine nitration is an oxidative post-translational protein modification relevant to various patho...
Protein tyrosine nitration (PTN) is a post-translational modification occurring under the action of ...
Protein 3-nitrotyrosine is a post-translational modification that commonly arises from the nitration...
Protein oxidation is increasingly recognised as an important modulator of biochemical pathways contr...
Protein tyrosine nitration (PTN) is a post-translational modification occurring under the action of ...
AbstractProteins are targets of reactive species and detection of oxidatively modified proteins is o...
Protein post-translational modifications are of great interest due to their effects on protein struc...
The physiologically important free radicals, nitrogen monoxide and superoxide, can combine to form t...
Nitric oxide (·NO) is a diffusible messenger implicated in Trypanosoma cruzi resistance. Excess prod...