Human Adult Neurogenesis: Evidence and Remaining Questions

Renewed discussion about whether or not adult neurogenesis exists in the human hippocampus, and the nature and strength of the supporting evidence, has been reignited by two prominently published reports with opposite conclusions. Here, we summarize the state of the field and argue that there is currently no reason to abandon the idea that adult-generated neurons make important functional contributions to neural plasticity and cognition across the human lifespan.Fil: Kempermann, Gerd. Technische Universität Dresden; AlemaniaFil: Gage, Fred H.. Salk Institute for Biological Studies; Estados UnidosFil: Aigner, Ludwig. Paracelsus Medical University; AustriaFil: Song, Hongjun. University of Pennsylvania; Estados UnidosFil: Curtis, Maurice A.. University of Auckland; Nueva ZelandaFil: Thuret, Sandrine. King's College London; Reino UnidoFil: Kuhn, H. Georg. University of Gothenburg; AlemaniaFil: Jessberger, Sebastian. Universitat Zurich; SuizaFil: Frankland, Paul W.. Hospital for Sick Children; CanadáFil: Cameron, Heather A.. National Institutes of Health; Estados UnidosFil: Gould, Elizabeth. University of Princeton; Estados UnidosFil: Hen, Rene. Columbia University; Estados UnidosFil: Abrous, D. Nora. Inserm; FranciaFil: Toni, Nicolas. Lausanne University Hospital; SuizaFil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Zhao, Xinyu. University Of Wisconsin. School Of Medicine And Public Health.; Estados UnidosFil: Lucassen, Paul J.. University of Amsterdam; Países BajosFil: Frisén, Jonas. Karolinska Institute; Sueci