Neuroprotective effect of melatonin loaded in ethylcellulose nanoparticles applied topically in a retinal degeneration model in rabbits
- Bessone, Carolina del Valle
- Martinez, Sofía Inés
- Luna, José Domingo
- Márquez, Marilyn A.
- Ramirez, Maria Laura
- Allemandi, Daniel Alberto
- Carpentieri, Agata Rita
- Quinteros, Daniela Alejandra
DOIAbstract
We are reporting for the first time the synthesis and application of an innovative nanometric system for the controlled topic release of melatonin in the retina. The ethylcellulose nanocapsules were characterized by diverse physicochemical techniques (scanning electron microscopy, zeta potential, hydrodynamic diameters) and an in vitro release study was done. A complete ex vivo and in vivo trans-corneal permeation and an irritation study were carried out with the new formulations in albino rabbits, to which a retinal degenerative model was induced. The results obtained demonstrate that the in vitro release of melatonin (1 mg/mL and 2 mg/mL) transported by nanocapsules is slower when compared to a solution of melatonin. Greater penetration o...
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