Partial Reversal of Striatal Damage by Palmitoylethanolamide Administration Following Perinatal Asphyxia
- Udovin, Lucas
- Kobiec, Tamara
- Herrera, María Inés
- Toro Urrego, Nicolas
- Kusnier, Carlos Federico
- Kolliker Frers, Rodolfo Alberto
- Ramos Hryb, Ana Belen
- Luaces, Juan Pablo
- Otero-losada, Matilde Estela
- Capani, Francisco
DOIAbstract
Perinatal asphyxia (PA) is a clinical condition brought by a birth temporary oxygen deprivation associated with long-term damage in the corpus striatum, one of the most compromised brain areas. Palmitoylethanolamide (PEA) is a neuromodulator well known for its protective effects in brain injury models, including PA, albeit not deeply studied regarding its particular effects in the corpus striatum following PA. Using Bjelke et al. (1991) PA model, full-term pregnant rats were decapitated, and uterus horns were placed in a water bath at 37°C for 19 min. One hour later, the pups were injected with PEA 10 mg/kg s.c., and placed with surrogate mothers. After 30 days, the animals were perfused, and coronal striatal sections were collected to anal...
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