Bone marrow/bone pre-metastatic niche for breast cancer cells colonization: The role of mesenchymal stromal cells
- Sanmartin, María Cecilia
- Borzone, Francisco Raúl
- Giorello, Maria Belen
- Pacienza, Natalia Alejandra
- Yannarelli, Gustavo Gabriel
- Chasseing, Norma Alejandra
DOIAbstract
Breast cancer is one of the most common oncological pathologies in women worldwide. While its early diagnosis has considerably improved, about 70 % of advanced patients develop bone metastases with a high mortality rate. Several authors demonstrated that primary breast cancer cells prepare their future metastatic niche –known as the pre-metastatic niche- to turn it into an “optimal soil” for colonization. The role of the different cellular components of the bone marrow/bone niche in bone metastasis has been well described. However, studying the changes that occur in this microenvironment before tumor cells arrival has become a novel research field. Therefore, the purpose of this review is to describe the current knowledge about the modulati...
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