Evaluation of T-Cell Responses Against Shared Melanoma Associated Antigens and Predicted Neoantigens in Cutaneous Melanoma Patients Treated With the CSF-470 Allogeneic Cell Vaccine Plus BCG and GM-CSF
- Podaza, Enrique Arturo
- Carri, Ibel
- Aris, Mariana
- Von Euw, Erika María
- Bravo, Alicia Ines
- Blanco, Paula
- Ortiz Wilczyñski, Juan Manuel
- Koile, Daniel Isaac
- Yankilevich, Patricio
- Nielsen, Morten
- Mordoh, Jose
- Barrio, Maria Marcela
DOIAbstract
The CSF-470 vaccine consists of lethally-irradiated allogeneic cells derived from four cutaneous melanoma cell lines administered plus BCG and GM-CSF as adjuvants. In an adjuvant phase II study vs. IFN-α2b, the vaccine significantly prolonged the distant metastasis-free survival (DMFS) of stages IIB-IIC-III melanoma patients with evidence of the induction of immune responses against vaccine cells. Purpose: The aim of this study was to analyze the antigens against which the immune response was induced, as well as the T-helper profile and lytic ability of immune cells after CSF-470 treatment. Methods: HLA-restricted peptides from tumor-associated antigens (TAAs) were selected from TANTIGEN database for 13 evaluable vaccinated patients. In add...
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