Hypothyroidism-related zinc deficiency leads to suppression of T lymphocyte activity
- Paulazo, Maria Alejandra
- Klecha, Alicia Juana
- Sterle, Helena Andrea
- Valli, Eduardo
- Torti, Horacio
- Cayrol, Maria Florencia
- Barreiro Arcos, María Laura
- Cremaschi, Graciela Alicia
DOIAbstract
Purpose: Hypothyroidism has been shown to induce immunosuppression and both the thyroid status and immunity are affected by zinc deficiency. However, the impact of hypothyroidism on zinc metabolism and its possible relationship with the immune status has not yet been deeply explored. Here, our aim was to study whether hypothyroidism may alter zinc metabolism and thus lead to the impairment of T lymphocyte activity. Methods: Variations in the distribution of zinc in the body were evaluated in PTU-treated hypothyroid mice. The effects of hypothyroidism and zinc deficiency were studied on T lymphocyte proliferation after stimulation both in vitro and in vivo. For in vitro assays, thyroid hormone-free or zinc chelator (TPEN or DTPA)-supplemente...
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