Insect-specific viruses regulate vector competence in <em>Aedes aegypti</em> mosquitoes via expression of histone H4
- Olmo, Roenick P.
- Todjro, Yaovi M. H.
- Aguiar, Eric R. G. R.
- de Almeida, João Paulo P.
- Armache, Juliana N.
- de Faria, Isaque J. S.
- Ferreira, Flávia V.
- Silva, Ana Teresa S.
- de Souza, Kátia P. R.
- Vilela, Ana Paula P.
- Tan, Cheong H.
- Diallo, Mawlouth
- Gaye, Alioune
- Paupy, Christophe
- Obame-Nkoghe, Judicaël
- Visser, Tessa M.
- Koenraadt, Constantianus J. M.
- Wongsokarijo, Merril A.
- Cruz, Ana Luiza C.
- Prieto, Mariliza T.
- Parra, Maisa C. P.
- Nogueira, Maurício L.
- Avelino-Silva, Vivian
- Mota, Renato N.
- Borges, Magno A. Z.
- Drumond, Betânia P.
- Kroon, Erna G.
- Sedda, Luigi
- Marois, Eric
- Imler, Jean-Luc
- Marques, João T.
DOIAbstract
Aedes aegypti and Aedes albopictus are major mosquito vectors for arthropod-borne viruses (arboviruses) such as dengue (DENV) and Zika (ZIKV) viruses. Mosquitoes also carry insect-specific viruses (ISVs) that may affect the transmission of arboviruses. Here, we analyzed the global virome in urban Aedes mosquitoes and observed that two insect-specific viruses, Phasi Charoen-like virus (PCLV) and Humaita Tubiacanga virus (HTV), were the most prevalent in A. aegypti worldwide except for African cities, where transmission of arboviruses is low. Spatiotemporal analysis revealed that presence of HTV and PCLV led to a 200% increase in the chances of having DENV in wild mosquitoes. In the laboratory, we showed that HTV and PCLV prevented downregula...
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