Prevalence analysis of hand, foot and mouth disease in China, 2008-2018

Objective: To analyze the prevalence of hand, foot and mouth disease (HFMD) in China during 2008-2018 and to provide reference for the prevention and control of HFMD. Methods: Literature eligible for selection was retrieved from the China's national knowledge infrastructure project (CNKI), and data from 2008-2018 Chinese HFMD reports were systematically analyzed. Excel and SPSS 20.00 were used for statistical analysis, and GraphPad Prism 6 was used for mapping. Results: The analysis showed that the average incidence rate of HFMD in China from 2008 to 2018 was 123.37±93.14 cases per 100,000 people, with a male-to-female ratio of (1.50±0.15):1, and the vast majority of cases were concentrated in the under-5 age group, mainly in scattered children. The time of onset of HFMD showed obvious seasonal characteristics, in which single-peak provinces were higher than double-peak provinces, with double-peak trends in April-July and October-November, respectively, and single-peak trends mainly in May-July. Based on the spatial distribution study, the incidence pattern showed obvious regional differences (P