Maculopapular Rash Related to Atomoxetine: Case Report

Exanthematous drug eruptions, also known as maculopapular drug eruptions, are the most common drug-induced hypersensitivity reactions. Pruritus, urticaria, exanthematous rash, fixed drug eruption, photosensitivity, pigmentation and alopecia are common skin reactions to psychotropic medications. Atomoxetine (ATX), a selective inhibitor of presynaptic norepinephrine transporters (SNRI), is classified as a non-stimulant and is commonly used in the treatment of attention deficit hyperactivity disorder (ADHD). It also binds to dopamine and serotonin transporters with a low affinity. Abdominal pain, loss of appetite, somnolence, irritability, fatigue, dizziness and dyspepsia are the most common side effects of ATX. Major cutaneous drug reactions with SNRIs are rarely reported in the literature. Here we present an eight-yearold girl diagnosed with ADHD who had a drug-induced skin reaction after an increase in the dosage of ATX treatment