Rodent studies have proposed that adolescent susceptibility to substance use is at least partly due to adolescents experiencing reduced aversive effects of drugs compared to adults. We thus investigated methamphetamine (meth) conditioned place preference/aversion (CPP/CPA) in adolescent and adult mice in both sexes using a high dose of meth (3 mg/kg) or saline as controls. Mice tagged with green-fluorescent protein (GFP) at Drd1a or Drd2 were used so that dopamine receptor 1 (D1) and 2 (D2) expression within the insular cortex (insula) could be quantified. There are sex differences in how the density of D1+ and D2+ cells in the insula changes across adolescence that may be related to drug-seeking behaviors. Immunohistochemistry followed by ...
This study analyzed the role of dopamine D1 and D2 receptors in methylphenidate (MPH) conditioned pl...
The age at which drug use begins is a critical factor in predicting future drug use liability. It is...
Adderall is a schedule II drug because of its medicinal use and high abuse potential, which may lead...
Rodent studies have proposed that adolescent susceptibility to substance use is at least partly due ...
Adolescence marks a particularly vulnerable period to developing substance use disorders. Human and ...
© 2020 Ellen Rose CullityMethamphetamine (meth) is a significant social and public health concern wo...
We used a conditioned place preference paradigm to test the rewarding effects of methamphetamine (1m...
Methamphetamine (METH) is a highly exploited, psycho-stimulant drug that leads to neurotoxicity from...
Methamphetamine (METH) is a psychostimulant drug that causes severe physical and mental effect on it...
Vulnerability to drug addiction in adolescents (ADOLs) may lead to faster rates of addiction and hig...
Amphetamine (AMPH) causes an increase of dopamine (DA) levels in the central nervous system by inhib...
Exposure to methamphetamine during brain development impairs cognition in children and adult rodents...
Methylphenidate (MPH) is a psychostimulant drug that is commonly prescribed for Attention Deficit-Hy...
Methylphenidate (MPH) (e.g., RitalinTM), prescriptions have significantly increased concomitant with...
Reinstatement of conditioned place preferences have been used to investigate physiological mechanism...
This study analyzed the role of dopamine D1 and D2 receptors in methylphenidate (MPH) conditioned pl...
The age at which drug use begins is a critical factor in predicting future drug use liability. It is...
Adderall is a schedule II drug because of its medicinal use and high abuse potential, which may lead...
Rodent studies have proposed that adolescent susceptibility to substance use is at least partly due ...
Adolescence marks a particularly vulnerable period to developing substance use disorders. Human and ...
© 2020 Ellen Rose CullityMethamphetamine (meth) is a significant social and public health concern wo...
We used a conditioned place preference paradigm to test the rewarding effects of methamphetamine (1m...
Methamphetamine (METH) is a highly exploited, psycho-stimulant drug that leads to neurotoxicity from...
Methamphetamine (METH) is a psychostimulant drug that causes severe physical and mental effect on it...
Vulnerability to drug addiction in adolescents (ADOLs) may lead to faster rates of addiction and hig...
Amphetamine (AMPH) causes an increase of dopamine (DA) levels in the central nervous system by inhib...
Exposure to methamphetamine during brain development impairs cognition in children and adult rodents...
Methylphenidate (MPH) is a psychostimulant drug that is commonly prescribed for Attention Deficit-Hy...
Methylphenidate (MPH) (e.g., RitalinTM), prescriptions have significantly increased concomitant with...
Reinstatement of conditioned place preferences have been used to investigate physiological mechanism...
This study analyzed the role of dopamine D1 and D2 receptors in methylphenidate (MPH) conditioned pl...
The age at which drug use begins is a critical factor in predicting future drug use liability. It is...
Adderall is a schedule II drug because of its medicinal use and high abuse potential, which may lead...