Mitochondria are the main bioenergetic organelles of cells. Exposure to chemicals targeting mitochondria therefore generally results in the development of toxicity. The cellular response to perturbations in cellular energy production is a balance between adaptation, by reorganisation and organelle biogenesis, and sacrifice, in the form of cell death. In homeostatic conditions, aerobic mitochondrial energy production requires the maintenance of a mitochondrial membrane potential (MMP). Chemicals can perturb this MMP, and the extent of this perturbation depends both on the pharmacokinetics of the chemicals and on downstream MMP dynamics. Here we obtain a quantitative understanding of mitochondrial adaptation upon exposure to various mitochond...
AbstractIn mitochondria the opening of a large proteinaceous pore, the “mitochondrial permeability t...
<p>(A) Differentiated human neuronal cultures were loaded with mitochondrial membrane indicator TMRM...
Small molecules are pharmacological tools of considerable value for dissecting complex biological pr...
Mitochondria are the main bioenergetic organelles of cells. Exposure to chemicals targeting mitochon...
Evidence is mounting for the central role of mitochondrial dysfunction in several pathologies includ...
Mitochondrial membrane potential (Deltapsi) is key to mitochondrial function and cellular survival. ...
Cells can adjust their mitochondrial morphology by altering the balance between mitochondrial fissio...
Because of its importance in the chemiosmotic theory, mitochondrial membrane potential has been the ...
Technological advances in molecular biology have enabled high-throughput screening (HTS) of large ch...
Summary The mitochondrial membrane potential (Δψm) is a major determinant and indicator of cell fate...
The mitochondrial membrane potential (Δψm) is a major determinant and indicator of cell fate, but it...
SummaryThe mitochondrial membrane potential (Δψm) is a major determinant and indicator of cell fate,...
Mitochondrial perturbation has been recognized as a contributing factor to various drug-induced orga...
Mitochondrial perturbation is a key event in chemical-induced organ toxicities that is incompletely ...
<p><b>A) Fluorescence microscopy</b> of MMP in live NPCs from patient (SNCA-Tri) and control (Ctrl) ...
AbstractIn mitochondria the opening of a large proteinaceous pore, the “mitochondrial permeability t...
<p>(A) Differentiated human neuronal cultures were loaded with mitochondrial membrane indicator TMRM...
Small molecules are pharmacological tools of considerable value for dissecting complex biological pr...
Mitochondria are the main bioenergetic organelles of cells. Exposure to chemicals targeting mitochon...
Evidence is mounting for the central role of mitochondrial dysfunction in several pathologies includ...
Mitochondrial membrane potential (Deltapsi) is key to mitochondrial function and cellular survival. ...
Cells can adjust their mitochondrial morphology by altering the balance between mitochondrial fissio...
Because of its importance in the chemiosmotic theory, mitochondrial membrane potential has been the ...
Technological advances in molecular biology have enabled high-throughput screening (HTS) of large ch...
Summary The mitochondrial membrane potential (Δψm) is a major determinant and indicator of cell fate...
The mitochondrial membrane potential (Δψm) is a major determinant and indicator of cell fate, but it...
SummaryThe mitochondrial membrane potential (Δψm) is a major determinant and indicator of cell fate,...
Mitochondrial perturbation has been recognized as a contributing factor to various drug-induced orga...
Mitochondrial perturbation is a key event in chemical-induced organ toxicities that is incompletely ...
<p><b>A) Fluorescence microscopy</b> of MMP in live NPCs from patient (SNCA-Tri) and control (Ctrl) ...
AbstractIn mitochondria the opening of a large proteinaceous pore, the “mitochondrial permeability t...
<p>(A) Differentiated human neuronal cultures were loaded with mitochondrial membrane indicator TMRM...
Small molecules are pharmacological tools of considerable value for dissecting complex biological pr...