SARS-CoV-2 in children with cancer or after haematopoietic stem cell transplant : An analysis of 131 patients
- Haeusler, Gabrielle M
- Ammann, Roland A
- Carlesse, Fabianne
- Groll, Andreas H
- Averbuch, Dina
- Castagnola, Elio
- Agyeman, Philipp K A
- Phillips, Bob
- Gilli, Flávio
- Solopova, Galina
- Attarbaschi, Andishe
- Wegehaupt, Oliver
- Speckmann, Carsten
- Sung, Lillian
- Lehrnbecher, Thomas
DOIAbstract
PURPOSE: There are limited data on SARS-CoV-2 (COVID-19) infection in children with cancer or after haematopoietic stem cell transplant (HSCT). We describe the severity and outcomes of SARS-COV-2 in these patients and identify factors associated with severe disease. METHODS: This was a multinational, observational study of children (aged <19 years) with cancer or HSCT and SARS-CoV-2 confirmed by polymerase chain reaction. COVID-19 was classified as asymptomatic, mild, moderate, severe or critical (≥1 organ support). Exact polytomous regression was used to determine the relationship between clinical variables and disease severity. RESULTS: One hundred and thirty-one patients with COVID-19 across 10 countries were identified (median age 8 yea...
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