The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals
- Yusuke Moritoh
- Shin-ichi Abe
- Hiroki Akiyama
- Akihiro Kobayashi
- Ryokichi Koyama
- Ryoma Hara
- Shizuo Kasai
- Masanori Watanabe
Publication date
August 2021
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
Inositol hexakisphosphate kinase (IP6K) is involved in diverse cellular signalling pathways, but the physiological roles of IP6K in vivo remain unknown in mammals. Here, the authors show that the enzymatic activity of IP6K is essential for phosphate regulation in vivo
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