Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells
- Aydan Bulut-Karslioglu
- Hu Jin
- Yun-Kyo Kim
- Brandon Cho
- Marcela Guzman-Ayala
- Andrew J. K. Williamson
- Miroslav Hejna
- Maximilian Stötzel
- Anthony D. Whetton
- Jun S. Song
- Miguel Ramalho-Santos
Publication date
August 2021
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
The chromatin remodeler Chd1 mediates hypertranscription in embryonic stem (ES) cells and has been shown to associate with genes transcribed by RNA Polymerase (Pol) I and II. Here the authors provide mechanistic insights into this process and reveal that Chd1 is involved in protecting genome integrity at promoter regions by preventing DNA break accumulation
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