CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research
- Sylwia D. Boltryk
- Armin Passecker
- Arne Alder
- Eilidh Carrington
- Marga van de Vegte-Bolmer
- Geert-Jan van Gemert
- Alex van der Starre
- Hans-Peter Beck
- Robert W. Sauerwein
- Taco W. A. Kooij
- Nicolas M. B. Brancucci
- Nicholas I. Proellochs
- Tim-Wolf Gilberger
- Till S. Voss
Publication date
August 2021
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
During each replication cycle of P. falciparum in the human bloodstream, a small proportion of parasites commits to sexual development and differentiates into transmission-relevant gametocytes. Applying CRISPR-based genome editing, Boltryk et al. engineer P. falciparum lines with sexual commitment rates of 75% to promote future studies on gametocyte biology
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