Epithelial cell therapies have been at an impasse because of inefficient methods of transplantation to solid organs. Patch grafting strategies were established enabling transplantation of ≥107th organoids/patch of porcine GFP+ biliary tree stem/progenitors into livers of wild type hosts. Grafts consisted of organoids embedded in soft (~100 Pa) hyaluronan hydrogels, both prepared in serum-free Kubota's Medium; placed against target sites; covered with a silk backing impregnated with more rigid hyaluronan hydrogels (~700 Pa); and use of the backing to tether grafts with sutures or glue to target sites. Hyaluronan coatings (~200–300 Pa) onto the serosal surface of the graft served to minimize adhesions with neighboring organs. The organ's clea...
Advances in our understanding of the biology of stem cells and their niches have provided the necess...
The continuing shortage of donor organs has been a major roadblock in orthotopic liver transplantati...
The liver is one of the body's tissues that has regenerative abilities. But if the damage is too muc...
Cell therapies are potential alternatives to organ transplantation for liver failure or dysfunction ...
Background: Cell therapy of liver diseases with human biliary tree stem cells (hBTSCs) is biased by ...
Cell adhesion is essential for survival, it plays important roles in physiological cell functions, a...
Currently, the only effective treatment for end-stage liver diseases is liver transplantation. Howev...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, Februar...
In the worldwide context of graft shortage, several strategies have been explored to increase the nu...
The increasing shortage of donors and the adverse effects of immunosuppression have restricted the i...
BackgroundLiver organoids show potential for development as a tissue replacement therapy for patient...
In Europe alone, each year 5500 people require a life-saving liver transplantation, but 18% die befo...
The gap between patients on transplant waiting lists and available donor organs is steadily increasi...
Over the last decade new methods are explored in the field of tissue engineering to minimize the don...
While the healthy liver is capable of rapidly regenerating after acute injury, patients with severe ...
Advances in our understanding of the biology of stem cells and their niches have provided the necess...
The continuing shortage of donor organs has been a major roadblock in orthotopic liver transplantati...
The liver is one of the body's tissues that has regenerative abilities. But if the damage is too muc...
Cell therapies are potential alternatives to organ transplantation for liver failure or dysfunction ...
Background: Cell therapy of liver diseases with human biliary tree stem cells (hBTSCs) is biased by ...
Cell adhesion is essential for survival, it plays important roles in physiological cell functions, a...
Currently, the only effective treatment for end-stage liver diseases is liver transplantation. Howev...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, Februar...
In the worldwide context of graft shortage, several strategies have been explored to increase the nu...
The increasing shortage of donors and the adverse effects of immunosuppression have restricted the i...
BackgroundLiver organoids show potential for development as a tissue replacement therapy for patient...
In Europe alone, each year 5500 people require a life-saving liver transplantation, but 18% die befo...
The gap between patients on transplant waiting lists and available donor organs is steadily increasi...
Over the last decade new methods are explored in the field of tissue engineering to minimize the don...
While the healthy liver is capable of rapidly regenerating after acute injury, patients with severe ...
Advances in our understanding of the biology of stem cells and their niches have provided the necess...
The continuing shortage of donor organs has been a major roadblock in orthotopic liver transplantati...
The liver is one of the body's tissues that has regenerative abilities. But if the damage is too muc...