Intracellular metabolism of excess glucose induces mitochondrial dysfunction and diversion of glycolytic intermediates into branch pathways, leading to cell injury and inflammation. Hyperglycemia-driven overproduction of mitochondrial superoxide was thought to be the initiator of these biochemical changes, but accumulating evidence indicates that mitochondrial superoxide generation is dispensable for diabetic complications development. Here we tested the hypothesis that hypoxia inducible factor (HIF)-1α and related bioenergetic changes (Warburg effect) play an initiating role in glucotoxicity. By using human endothelial cells and macrophages, we demonstrate that high glucose (HG) induces HIF-1α activity and a switch from oxidative metabolis...
Angiogenesis is tightly regulated in order to provide adequate supply of nutrients and oxygen for no...
Twenty years have passed since Brownlee and colleagues proposed a single unifying mechanism for diab...
Diabetes Mellitus is an ongoing epidemic, causing individual suffering as well as constituting an en...
Intracellular metabolism of excess glucose induces mitochondrial dysfunction and diversion of glycol...
Background: Excessive production of mitochondrial reactive oxygen species (ROS) is a central mechani...
Hypoxia-inducible factor (HIF) 1α is a metabolic regulator that plays an important role in immunolog...
Background and Aim: Chronic exposure to high glucose concentrations markedly alters β-cell gene expr...
International audienceThe activation of glucose-6-phosphatase (G6Pase), a key enzyme of endogenous g...
Chronic complications of diabetes represent a major medical and economical concern. It is an imperat...
Diabetes Mellitus (DM) is a major concern for societies and healthcare systems globally. DMassociate...
Recent reports indicate that the hypoxia-induced factor (HIF1α) and the Warburg effect play an initi...
The in vivo response to lipopolysaccharide (LPS) occurs rapidly and has profound physiological and m...
Methylglyoxal (MG) is a reactive á-oxoaldehyde and a glucose metabolite. Previous studies in our la...
Metabolic dysfunction of endothelial cells in hyperglycemia contributes to the development of vascul...
We used cultured endothelial cells as a model to examine whether up-regulation of aldolase B and enh...
Angiogenesis is tightly regulated in order to provide adequate supply of nutrients and oxygen for no...
Twenty years have passed since Brownlee and colleagues proposed a single unifying mechanism for diab...
Diabetes Mellitus is an ongoing epidemic, causing individual suffering as well as constituting an en...
Intracellular metabolism of excess glucose induces mitochondrial dysfunction and diversion of glycol...
Background: Excessive production of mitochondrial reactive oxygen species (ROS) is a central mechani...
Hypoxia-inducible factor (HIF) 1α is a metabolic regulator that plays an important role in immunolog...
Background and Aim: Chronic exposure to high glucose concentrations markedly alters β-cell gene expr...
International audienceThe activation of glucose-6-phosphatase (G6Pase), a key enzyme of endogenous g...
Chronic complications of diabetes represent a major medical and economical concern. It is an imperat...
Diabetes Mellitus (DM) is a major concern for societies and healthcare systems globally. DMassociate...
Recent reports indicate that the hypoxia-induced factor (HIF1α) and the Warburg effect play an initi...
The in vivo response to lipopolysaccharide (LPS) occurs rapidly and has profound physiological and m...
Methylglyoxal (MG) is a reactive á-oxoaldehyde and a glucose metabolite. Previous studies in our la...
Metabolic dysfunction of endothelial cells in hyperglycemia contributes to the development of vascul...
We used cultured endothelial cells as a model to examine whether up-regulation of aldolase B and enh...
Angiogenesis is tightly regulated in order to provide adequate supply of nutrients and oxygen for no...
Twenty years have passed since Brownlee and colleagues proposed a single unifying mechanism for diab...
Diabetes Mellitus is an ongoing epidemic, causing individual suffering as well as constituting an en...