Add to ORKGA key topic in precision medicine is to develop pharmacological treatments optimised for any given individual (personalised treatments). Model-based approaches (aka In Silico Clinical Trials, ISCT) aim at achieving this goal, by enabling the automatic synthesis and verification of personalised treatments via simulation, before they are actually administered to patients. In this short paper, we introduce the area of ISCT, and review our approach to the in silico automatic synthesis of optimal personalised treatments, where numerical simulation of quantitative models of the human physiology and reactions to drugs is driven by Artificial Intelligence global search
Computational methods play a key role in the design of therapeutically important molecules for moder...
Abstract Motivation Model-based approaches to sa...
A clinical trial is an essential step in drug development, which is often costly and time-consuming....
In Silico Clinical Trials (ISCT), i.e. clinical experimental campaigns carried out by means of compu...
In-Silico Clinical Trials (ISCT), i.e., clinical experimental campaigns carried out by means of comp...
A Virtual Patient (VP) is a computational model accounting for individualised (patho-) physiology an...
Model-based approaches to safety and efficacy assessment of pharmacological treatments (In Silico Cl...
The past decade has produced overwhelming evidence that changes in the health status of individuals,...
In recent years, the use of artificial intelligence (AI) in health care has risen steadily, includin...
Regulatory agencies encourage computer modeling and simulation to reduce the time and cost of clinic...
In Silico Clinical Trials (ISCT), i.e., clinical experimental campaigns carried out by means of comp...
CRC is one of the deadliest forms of tumor for adult humans, which often requires expensive and high...
Motivation Model-based approaches to safety and efficacy assessment of pharmacological drugs, tre...
Personalised modelling offers a new and effective approach for the study in pattern recognition and ...
The simulation of therapeutic models and clinical trial simulation have recently attracted attention...
Computational methods play a key role in the design of therapeutically important molecules for moder...
Abstract Motivation Model-based approaches to sa...
A clinical trial is an essential step in drug development, which is often costly and time-consuming....
In Silico Clinical Trials (ISCT), i.e. clinical experimental campaigns carried out by means of compu...
In-Silico Clinical Trials (ISCT), i.e., clinical experimental campaigns carried out by means of comp...
A Virtual Patient (VP) is a computational model accounting for individualised (patho-) physiology an...
Model-based approaches to safety and efficacy assessment of pharmacological treatments (In Silico Cl...
The past decade has produced overwhelming evidence that changes in the health status of individuals,...
In recent years, the use of artificial intelligence (AI) in health care has risen steadily, includin...
Regulatory agencies encourage computer modeling and simulation to reduce the time and cost of clinic...
In Silico Clinical Trials (ISCT), i.e., clinical experimental campaigns carried out by means of comp...
CRC is one of the deadliest forms of tumor for adult humans, which often requires expensive and high...
Motivation Model-based approaches to safety and efficacy assessment of pharmacological drugs, tre...
Personalised modelling offers a new and effective approach for the study in pattern recognition and ...
The simulation of therapeutic models and clinical trial simulation have recently attracted attention...
Computational methods play a key role in the design of therapeutically important molecules for moder...
Abstract Motivation Model-based approaches to sa...
A clinical trial is an essential step in drug development, which is often costly and time-consuming....