Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study
- Langenberg C
- Sharp S
- Forouhi NG
- Franks PW
- Schulze MB
- Kerrison N
- Ekelund U
- Barroso I
- Panico S
- Tormo MJ
- Spranger J
- Griffin S
- van der Schouw YT
- Amiano P
- Ardanaz E
- Arriola L
- Balkau B
- Barricarte A
- Beulens JWJ
- Boeing H
- Bueno-de-Mesquita HB
- Buijsse B
- Lopez MDC
- Clavel-Chapelon F
- Crowe FL
- de Lauzon-Guillan B
- Deloukas P
- Dorronsoro M
- Drogan D
- Froguel P
- Gonzalez C
- Grioni S
- Groop L
- Groves C
- Hainaut P
- Halkjaer J
- Hallmans G
- Hansen T
- Castano JMH
- Kaaks R
- Key TJ
- Khaw KT
- Koulman A
- Mattiello A
- Navarro C
- Nilsson P
- Norat T
- Overvad K
- Palla L
- Palli D
- Pedersen O
- Peeters PH
- Quiros JR
- Ramachandran A
- Rodriguez-Suarez L
- Rolandsson O
- Romaguera D
- Romieu I
- Sacerdote C
- Sanchez MJ
- Sandbaek A
- Slimani N
- Sluijs I
- Spijkerman AMW
- Teucher B
- Tjonneland A
- Tumino R
- van der A DL
- Verschuren WMM
- Tuomilehto J
- Feskens E
- McCarthy M
- Riboli E
- Wareham NJ
DOIAbstract
Studying gene-lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene-lifestyle studies are lacking. This case-cohort study aims to investigate how genetic and potentially modifiable lifestyle and behavioural factors, particularly diet and physical activity, interact in their influence on the risk of developing type 2 diabetes. Incident cases of type 2 diabetes occurring in European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts between 1991 and 2007 from eight of the ten EPIC countries were ascertained and ...
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