Replication in Human Intestinal Enteroids of Infectious Norovirus from Vomit Samples
- Hagbom, Marie
- Lin, Jenny
- Falkeborn, Tina
- Serrander, Lena
- Albert, Jan
- Nordgren, Johan
- Sharma, Sumit
Publication date
January 2021
DOI Publisher
Centers for Disease Control and Prevention (CDC)Abstract
A typical clinical symptom of human norovirus infection is projectile vomiting. Although norovirus RNA and viral particles have been detected in vomitus, infectivity has not yet been reported. We detected replication-competent norovirus in 25% of vomit samples with a 13-fold to 714-fold increase in genomic equivalents, confirming infectious norovirus.Funding Agencies|Swedish Research CouncilSwedish Research CouncilEuropean Commission [3R 2017-01479]; ALF Grants, Region Ostergotland [LIO-934451]</p
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