Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies
- Cotugno N.
- Ruggiero A.
- Bonfante F.
- Petrara M. R.
- Zicari S.
- Pascucci G. R.
- Zangari P.
- De Ioris M. A.
- Santilli V.
- Manno E. C.
- Amodio D.
- Bortolami A.
- Pagliari M.
- Concato C.
- Linardos G.
- Campana A.
- Dona D.
- Giaquinto C.
- Bernardi S.
- Romani L.
- Pansa P.
- Chiurchiu S.
- Finocchi A.
- Cancrini C.
- Lancella L.
- Cursi L.
- De Luca M.
- Cutrera R.
- Sessa L.
- Morrocchi E.
- Medri C.
- Putignani L.
- Calo Carducci F. I.
- D'Argenio P.
- Ciofi degli Atti M.
- D'Amore C.
- Piccioni L.
- Di Giuseppe M.
- Jenkner A.
- Giancotta C.
- Krzysztofiak A.
- Brodin P.
- Rossi P.
- De Rossi A.
- Palma P.
DOIAbstract
As the global COVID-19 pandemic progresses, it is paramount to gain knowledge on adaptive immunity to SARS-CoV-2 in children to define immune correlates of protection upon immunization or infection. We analyzed anti-SARS-CoV-2 antibodies and their neutralizing activity (PRNT) in 66 COVID-19-infected children at 7 (±2) days after symptom onset. Individuals with specific humoral responses presented faster virus clearance and lower viral load associated with a reduced in vitro infectivity. We demonstrated that the frequencies of SARS-CoV-2-specific CD4+CD40L+ T cells and Spike-specific B cells were associated with the anti-SARS-CoV-2 antibodies and the magnitude of neutralizing activity. The plasma proteome confirmed the association ...
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