Genome-wide association study of circulating interleukin 6 levels identifies novel loci

Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-a Cytokine Response in a Danish Cohort

Margit Hørup Larsen
Anders Albrechtsen
Lise Wegner Thørner
Thomas Werge
Thomas Hansen
Ulrik Gether
Eva Haastrup
Henrik Ullum

August 2016

Background: Cytokine response plays a vital role in various human lipopolysaccharide (LPS) infectiou...

Whole blood gene expression and interleukin-6 levels.

Lin, H
Joehanes, R
Pilling, LC
Dupuis, J
Lunetta, KL
Ying, SX
Benjamin, EJ
Hernandez, Dena
Singleton, A
Melzer, D
Munson, PJ
Levy, D
Ferrucci, L
Murabito, JM

December 2014

This is the author’s version of a work that was accepted for publication in Genomics. Changes result...

Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α Cytokine Response in a Danish Cohort.

Margit Hørup Larsen
Anders Albrechtsen
Lise Wegner Thørner
Thomas Werge
Thomas Hansen
Ulrik Gether
Eva Haastrup
Henrik Ullum

Cytokine response plays a vital role in various human lipopolysaccharide (LPS) infectious and inflam...

Genome-wide association study of circulating interleukin 6 levels identifies novel loci

Ahluwalia, Tarunveer S.
Prins, Bram P.
Abdollahi, Mohammadreza
Armstrong, Nicola J.
Aslibekyan, Stella
Bain, Lisa
Jefferis, Barbara
Baumert, Jens
Beekman, Marian
Ben-Shlomo, Yoav
Bis, Joshua C.
Mitchell, Braxton D.
Geus, Eco de
Delgado, Graciela E.
Marek, Diana
Eriksson, Joel
Kajantie, Eero
Kanoni, Stavroula
Kemp, John P.
Lu, Chen
Marioni, Riccardo E.
McLachlan, Stela
Milaneschi, Yuri
Nolte, Ilja M.
Petrelis, Alexandros M.
Porcu, Eleonora
Sabater-Lleal, Maria
Naderi, Elnaz
Seppälä, Tina and Singhal
Spector, Tim
Stacey, David
Stathopoulou, Maria G.
Tanaka, Toshiko
Wannamethee, S. Goya
Whincup, Peter
Rotter, Jerome I.
Dehghan, Abbas
Boerwinkle, Eric
Psaty, Bruce M.
Snieder, Harold
Alizadeh, Behrooz Z.
Müller-Nurasyid, Martina

January 2021

Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties w...

Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci

Ahluwalia, T.
Prins, B.
Abdollahi, M.
Armstrong, N.
Aslibekyan, S.
Bain, L.
Jefferis, B.
Baumert, J.
Beekman, M.
Ben-Shlomo, Y.
Bis, J.
Mitchell, B.
de Geus, E.
Delgado, G.
Marek, D.
Eriksson, J.
Kajantie, E.
Kanoni, S.
Kemp, J.
Lu, C.
Marioni, R.
McLachlan, S.
Milaneschi, Y.
Nolte, I.
Petrelis, A.
Porcu, E.
Sabater-Lleal, M.
Naderi, E.
Seppala, I.
Shah, T.
Singhal, G.
Standl, M.
Teumer, A.
Thalamuthu, A.
Thiering, E.
Trompet, S.
Ballantyne, C.
Benjamin, E.
Casas, J.
Toben, C.
Dedoussis, G.
Deelen, J.
Durda, P.
Engmann, J.
Feitosa, M.
Grallert, H.
Hammarstedt, A.
Harris, S.
Homuth, G.
Hottenga, J.
Jalkanen, S.
Jamshidi, Y.
Jawahar, M.
Jess, T.
Kivimaki, M.
Kleber, M.
Lahti, J.
Liu, Y.
Marques-Vidal, P.
Mellstrom, D.
Mooijaart, S.
Muller-Nurasyid, M.
Penninx, B.
Revez, J.
Rossing, P.
Raikkonen, K.
Sattar, N.
Scharnagl, H.
Sennblad, B.
Silveira, A.
Pourcain, B.
Timpson, N.
Trollor, J.
Group, C.
van Dongen, J.
Van Heemst, D.
Visvikis-Siest, S.
Vollenweider, P.
Volker, U.
Waldenberger, M.
Willemsen, G.
Zabaneh, D.
Morris, R.
Arnett, D.
Baune, B.
Boomsma, D.
Chang, Y.
Deary, I.
Deloukas, P.
Eriksson, J.
Evans, D.
Ferreira, M.
Gaunt, T.
Gudnason, V.
Hamsten, A.
Heinrich, J.
Hingorani, A.
Humphries, S.
Jukema, J.
Koeing, W.
Kumari, M.
Kutalik, Z.
Lawlor, D.
Lehtimaki, T.
Marz, W.
Mather, K.
Naitza, S.
Nauck, M.
Ohlsson, C.
Price, J.
Raitakari, O.
Rice, K.
Sachdev, P.
Slagboom, P.
Sorensen, T.
Spector, T.
Stacey, D.
Stathopoulou, M.
Tanaka, T.
Wannamethee, S.
Whincup, P.
Rotter, J.
Dehghan, A.
Boerwinkle, E.
Psaty, B.
Snieder, H.
Alizadeh, B.

February 2021

Interleukin-6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties w...

Genome-wide association study of circulating interleukin 6 levels identifies novel loci.

Ahluwalia, T.S.
Prins, B.P.
Abdollahi, M.
Armstrong, N.J.
Aslibekyan, S.
Bain, L.
Jefferis, B.
Baumert, J.J.
Beekman, M.
Ben-Shlomo, Y.
Bis, J.C.
Mitchell, B.D.
de Geus, E.
Delgado, G.E.
Marek, D.
Eriksson, J.
Kajantie, E.
Kanoni, S.
Kemp, J.P.
Lu, C.
Marioni, R.E.
McLachlan, S.
Milaneschi, Y.
Nolte, I.M.
Petrelis, A.M.
Porcu, E.
Sabater-Lleal, M.
Naderi, E.
Seppälä, I.
Shah, T.
Singhal, G.
Standl, M.
Teumer, A.
Thalamuthu, A.
Thiering, E.
Trompet, S.
Ballantyne, C.M.
Benjamin, E.J.
Casas, J.P.
Toben, C.
Dedoussis, G.
Deelen, J.
Durda, P.
Engmann, J.
Feitosa, M.F.
Grallert, H.
Hammarstedt, A.
Harris, S.E.
Homuth, G.
Hottenga, J.J.
Jalkanen, S.
Jamshidi, Y.
Jawahar, M.C.
Jess, T.
Kivimaki, M.
Kleber, M.E.
Lahti, J.
Liu, Y.
Marques-Vidal, P.
Mellström, D.
Mooijaart, S.P.
Müller-Nurasyid, M.
Penninx, B.
Revez, J.A.
Rossing, P.
Räikkönen, K.
Sattar, N.
Scharnagl, H.
Sennblad, B.
Silveira, A.
Pourcain, B.S.
Timpson, N.J.
Trollor, J.
van Dongen, J.
van Heemst, D.
Visvikis-Siest, S.
Vollenweider, P.
Völker, U.
Waldenberger, M.
Willemsen, G.
Zabaneh, D.
Morris, R.W.
Arnett, D.K.
Baune, B.T.
Boomsma, D.I.
Chang, Y.C.
Deary, I.J.
Deloukas, P.
Eriksson, J.G.
Evans, D.M.
Ferreira, M.A.
Gaunt, T.
Gudnason, V.
Hamsten, A.
Heinrich, J.
Hingorani, A.
Humphries, S.E.
Jukema, J.W.
Koeing, W.
Kumari, M.
Kutalik, Z.
Lawlor, D.A.
Lehtimäki, T.
März, W.
Mather, K.
Naitza, S.
Nauck, M.
Ohlsson, C.
Price, J.F.
Raitakari, O.
Rice, K.
Sachdev, P.S.
Slagboom, E.
Sørensen, T.I.A.
Spector, T.
Stacey, D.
Stathopoulou, M.G.
Tanaka, T.
Wannamethee, S.G.
Whincup, P.
Rotter, J.I.
Dehghan, A.
Boerwinkle, E.
Psaty, B.M.
Snieder, H.
Alizadeh, B.Z.

January 2021

Interleukin-6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties w...

The Contribution of the Functional IL6R Polymorphism rs2228145, eQTLs and Other Genome-Wide SNPs to the Heritability of Plasma sIL-6R Levels

van Dongen, J.
Jansen, R.
Smit, D.J.A.
Hottenga, J.J.
Mbarek, H.
Willemsen, G.
Kluft, C.
Penninx, B.W.J.H.
Ferreira, M.A.
Boomsma, D.I.
de Geus, E.J.C.

January 2014

The non-synonymous SNP rs2228145 in the IL6R gene on chromosome 1q21.3 is associated with a wide ran...

ARTICLE Admixture Mapping of an Allele Affecting Interleukin 6 Soluble Receptor and Interleukin 6 Levels

David Reich
Nick Patterson
Vijaya Ramesh
Philip L. De Jager
Gavin J. Mcdonald
Arti T
Edwin Choy
Donglei Hu
Bani Tamraz
Ludmila Pawlikowska
Christina Wassel-fyr
Joseph M. Zmuda
Elad Ziv
For The Health

January 2015

Circulating levels of inflammatory markers can predict cardiovascular disease risk. To identify gene...

Admixture Mapping of an Allele Affecting Interleukin 6 Soluble Receptor and Interleukin 6 Levels

Reich, David
Patterson, Nick
Ramesh, Vijaya
De Jager, Philip L.
McDonald, Gavin J.
Tandon, Arti
Choy, Edwin
Hu, Donglei
Tamraz, Bani
Pawlikowska, Ludmila
Wassel-Fyr, Christina
Huntsman, Scott
Waliszewska, Alicja
Rossin, Elizabeth
Li, Rongling
Garcia, Melissa
Reiner, Alexander
Ferrell, Robert
Cummings, Steve
Kwok, Pui-Yan
Harris, Tamara
Zmuda, Joseph M.
Ziv, Elad

April 2007

Circulating levels of inflammatory markers can predict cardiovascular disease risk. To identify gene...

DNA variants, plasma levels and variability of Interleukin-6 in myocardial infarction survivors: Results from the AIRGENE study.

Ljungman, P.
Bellander, T.
Nyberg, F.
Lampa, E.
Jacquemin, B.
Kolz, M.
Lanki, T.
Mitropoulos, J.
Müller, M.
Picciotto, S.
Pistelli, R.
Rückerl, R.
Koenig, W.
Peters, A.

January 2009

Introduction: Increased levels of interleukin 6 (IL-6), a marker for systemic inflammation, have bee...

Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-a Cytokine Response in a Danish Cohort

Margit Hørup Larsen
Anders Albrechtsen
Lise Wegner Thørner
Thomas Werge
Thomas Hansen
Ulrik Gether
Eva Haastrup
Henrik Ullum

August 2016

Background: Cytokine response plays a vital role in various human lipopolysaccharide (LPS) infectiou...

Whole blood gene expression and interleukin-6 levels.

Lin, H
Joehanes, R
Pilling, LC
Dupuis, J
Lunetta, KL
Ying, SX
Benjamin, EJ
Hernandez, Dena
Singleton, A
Melzer, D
Munson, PJ
Levy, D
Ferrucci, L
Murabito, JM

December 2014

This is the author’s version of a work that was accepted for publication in Genomics. Changes result...

Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α Cytokine Response in a Danish Cohort.

Margit Hørup Larsen
Anders Albrechtsen
Lise Wegner Thørner
Thomas Werge
Thomas Hansen
Ulrik Gether
Eva Haastrup
Henrik Ullum

Cytokine response plays a vital role in various human lipopolysaccharide (LPS) infectious and inflam...

Genome-wide association study of circulating interleukin 6 levels identifies novel loci

Ahluwalia, Tarunveer S.
Prins, Bram P.
Abdollahi, Mohammadreza
Armstrong, Nicola J.
Aslibekyan, Stella
Bain, Lisa
Jefferis, Barbara
Baumert, Jens
Beekman, Marian
Ben-Shlomo, Yoav
Bis, Joshua C.
Mitchell, Braxton D.
Geus, Eco de
Delgado, Graciela E.
Marek, Diana
Eriksson, Joel
Kajantie, Eero
Kanoni, Stavroula
Kemp, John P.
Lu, Chen
Marioni, Riccardo E.
McLachlan, Stela
Milaneschi, Yuri
Nolte, Ilja M.
Petrelis, Alexandros M.
Porcu, Eleonora
Sabater-Lleal, Maria
Naderi, Elnaz
Seppälä, Tina and Singhal
Spector, Tim
Stacey, David
Stathopoulou, Maria G.
Tanaka, Toshiko
Wannamethee, S. Goya
Whincup, Peter
Rotter, Jerome I.
Dehghan, Abbas
Boerwinkle, Eric
Psaty, Bruce M.
Snieder, Harold
Alizadeh, Behrooz Z.
Müller-Nurasyid, Martina

January 2021

Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties w...

Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci

Ahluwalia, T.
Prins, B.
Abdollahi, M.
Armstrong, N.
Aslibekyan, S.
Bain, L.
Jefferis, B.
Baumert, J.
Beekman, M.
Ben-Shlomo, Y.
Bis, J.
Mitchell, B.
de Geus, E.
Delgado, G.
Marek, D.
Eriksson, J.
Kajantie, E.
Kanoni, S.
Kemp, J.
Lu, C.
Marioni, R.
McLachlan, S.
Milaneschi, Y.
Nolte, I.
Petrelis, A.
Porcu, E.
Sabater-Lleal, M.
Naderi, E.
Seppala, I.
Shah, T.
Singhal, G.
Standl, M.
Teumer, A.
Thalamuthu, A.
Thiering, E.
Trompet, S.
Ballantyne, C.
Benjamin, E.
Casas, J.
Toben, C.
Dedoussis, G.
Deelen, J.
Durda, P.
Engmann, J.
Feitosa, M.
Grallert, H.
Hammarstedt, A.
Harris, S.
Homuth, G.
Hottenga, J.
Jalkanen, S.
Jamshidi, Y.
Jawahar, M.
Jess, T.
Kivimaki, M.
Kleber, M.
Lahti, J.
Liu, Y.
Marques-Vidal, P.
Mellstrom, D.
Mooijaart, S.
Muller-Nurasyid, M.
Penninx, B.
Revez, J.
Rossing, P.
Raikkonen, K.
Sattar, N.
Scharnagl, H.
Sennblad, B.
Silveira, A.
Pourcain, B.
Timpson, N.
Trollor, J.
Group, C.
van Dongen, J.
Van Heemst, D.
Visvikis-Siest, S.
Vollenweider, P.
Volker, U.
Waldenberger, M.
Willemsen, G.
Zabaneh, D.
Morris, R.
Arnett, D.
Baune, B.
Boomsma, D.
Chang, Y.
Deary, I.
Deloukas, P.
Eriksson, J.
Evans, D.
Ferreira, M.
Gaunt, T.
Gudnason, V.
Hamsten, A.
Heinrich, J.
Hingorani, A.
Humphries, S.
Jukema, J.
Koeing, W.
Kumari, M.
Kutalik, Z.
Lawlor, D.
Lehtimaki, T.
Marz, W.
Mather, K.
Naitza, S.
Nauck, M.
Ohlsson, C.
Price, J.
Raitakari, O.
Rice, K.
Sachdev, P.
Slagboom, P.
Sorensen, T.
Spector, T.
Stacey, D.
Stathopoulou, M.
Tanaka, T.
Wannamethee, S.
Whincup, P.
Rotter, J.
Dehghan, A.
Boerwinkle, E.
Psaty, B.
Snieder, H.
Alizadeh, B.

February 2021

Interleukin-6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties w...

Genome-wide association study of circulating interleukin 6 levels identifies novel loci.

Ahluwalia, T.S.
Prins, B.P.
Abdollahi, M.
Armstrong, N.J.
Aslibekyan, S.
Bain, L.
Jefferis, B.
Baumert, J.J.
Beekman, M.
Ben-Shlomo, Y.
Bis, J.C.
Mitchell, B.D.
de Geus, E.
Delgado, G.E.
Marek, D.
Eriksson, J.
Kajantie, E.
Kanoni, S.
Kemp, J.P.
Lu, C.
Marioni, R.E.
McLachlan, S.
Milaneschi, Y.
Nolte, I.M.
Petrelis, A.M.
Porcu, E.
Sabater-Lleal, M.
Naderi, E.
Seppälä, I.
Shah, T.
Singhal, G.
Standl, M.
Teumer, A.
Thalamuthu, A.
Thiering, E.
Trompet, S.
Ballantyne, C.M.
Benjamin, E.J.
Casas, J.P.
Toben, C.
Dedoussis, G.
Deelen, J.
Durda, P.
Engmann, J.
Feitosa, M.F.
Grallert, H.
Hammarstedt, A.
Harris, S.E.
Homuth, G.
Hottenga, J.J.
Jalkanen, S.
Jamshidi, Y.
Jawahar, M.C.
Jess, T.
Kivimaki, M.
Kleber, M.E.
Lahti, J.
Liu, Y.
Marques-Vidal, P.
Mellström, D.
Mooijaart, S.P.
Müller-Nurasyid, M.
Penninx, B.
Revez, J.A.
Rossing, P.
Räikkönen, K.
Sattar, N.
Scharnagl, H.
Sennblad, B.
Silveira, A.
Pourcain, B.S.
Timpson, N.J.
Trollor, J.
van Dongen, J.
van Heemst, D.
Visvikis-Siest, S.
Vollenweider, P.
Völker, U.
Waldenberger, M.
Willemsen, G.
Zabaneh, D.
Morris, R.W.
Arnett, D.K.
Baune, B.T.
Boomsma, D.I.
Chang, Y.C.
Deary, I.J.
Deloukas, P.
Eriksson, J.G.
Evans, D.M.
Ferreira, M.A.
Gaunt, T.
Gudnason, V.
Hamsten, A.
Heinrich, J.
Hingorani, A.
Humphries, S.E.
Jukema, J.W.
Koeing, W.
Kumari, M.
Kutalik, Z.
Lawlor, D.A.
Lehtimäki, T.
März, W.
Mather, K.
Naitza, S.
Nauck, M.
Ohlsson, C.
Price, J.F.
Raitakari, O.
Rice, K.
Sachdev, P.S.
Slagboom, E.
Sørensen, T.I.A.
Spector, T.
Stacey, D.
Stathopoulou, M.G.
Tanaka, T.
Wannamethee, S.G.
Whincup, P.
Rotter, J.I.
Dehghan, A.
Boerwinkle, E.
Psaty, B.M.
Snieder, H.
Alizadeh, B.Z.

January 2021

Interleukin-6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties w...

The Contribution of the Functional IL6R Polymorphism rs2228145, eQTLs and Other Genome-Wide SNPs to the Heritability of Plasma sIL-6R Levels

van Dongen, J.
Jansen, R.
Smit, D.J.A.
Hottenga, J.J.
Mbarek, H.
Willemsen, G.
Kluft, C.
Penninx, B.W.J.H.
Ferreira, M.A.
Boomsma, D.I.
de Geus, E.J.C.

January 2014

The non-synonymous SNP rs2228145 in the IL6R gene on chromosome 1q21.3 is associated with a wide ran...

ARTICLE Admixture Mapping of an Allele Affecting Interleukin 6 Soluble Receptor and Interleukin 6 Levels

David Reich
Nick Patterson
Vijaya Ramesh
Philip L. De Jager
Gavin J. Mcdonald
Arti T
Edwin Choy
Donglei Hu
Bani Tamraz
Ludmila Pawlikowska
Christina Wassel-fyr
Joseph M. Zmuda
Elad Ziv
For The Health

January 2015

Circulating levels of inflammatory markers can predict cardiovascular disease risk. To identify gene...

Admixture Mapping of an Allele Affecting Interleukin 6 Soluble Receptor and Interleukin 6 Levels

Reich, David
Patterson, Nick
Ramesh, Vijaya
De Jager, Philip L.
McDonald, Gavin J.
Tandon, Arti
Choy, Edwin
Hu, Donglei
Tamraz, Bani
Pawlikowska, Ludmila
Wassel-Fyr, Christina
Huntsman, Scott
Waliszewska, Alicja
Rossin, Elizabeth
Li, Rongling
Garcia, Melissa
Reiner, Alexander
Ferrell, Robert
Cummings, Steve
Kwok, Pui-Yan
Harris, Tamara
Zmuda, Joseph M.
Ziv, Elad

April 2007

Circulating levels of inflammatory markers can predict cardiovascular disease risk. To identify gene...

DNA variants, plasma levels and variability of Interleukin-6 in myocardial infarction survivors: Results from the AIRGENE study.

Ljungman, P.
Bellander, T.
Nyberg, F.
Lampa, E.
Jacquemin, B.
Kolz, M.
Lanki, T.
Mitropoulos, J.
Müller, M.
Picciotto, S.
Pistelli, R.
Rückerl, R.
Koenig, W.
Peters, A.

January 2009

Introduction: Increased levels of interleukin 6 (IL-6), a marker for systemic inflammation, have bee...

Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-a Cytokine Response in a Danish Cohort

Margit Hørup Larsen
Anders Albrechtsen
Lise Wegner Thørner
Thomas Werge
Thomas Hansen
Ulrik Gether
Eva Haastrup
Henrik Ullum

August 2016

Background: Cytokine response plays a vital role in various human lipopolysaccharide (LPS) infectiou...

Whole blood gene expression and interleukin-6 levels.

Lin, H
Joehanes, R
Pilling, LC
Dupuis, J
Lunetta, KL
Ying, SX
Benjamin, EJ
Hernandez, Dena
Singleton, A
Melzer, D
Munson, PJ
Levy, D
Ferrucci, L
Murabito, JM

December 2014

This is the author’s version of a work that was accepted for publication in Genomics. Changes result...

Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α Cytokine Response in a Danish Cohort.

Margit Hørup Larsen
Anders Albrechtsen
Lise Wegner Thørner
Thomas Werge
Thomas Hansen
Ulrik Gether
Eva Haastrup
Henrik Ullum

Cytokine response plays a vital role in various human lipopolysaccharide (LPS) infectious and inflam...

Genome-wide association study of circulating interleukin 6 levels identifies novel loci

Abstract

Extracted data

Genome-wide association study of circulating interleukin 6 levels identifies novel loci

Abstract

Extracted data

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