Prognostic value of high-risk human papillomavirus DNA and p16INK4a immunohistochemistry in patients with anal cancer: An individual patient data meta-analysis
- Obermueller, Theresa
- Hautekiet, Joris
- Busto, Maria P
- Reynders, Dries
- Belgioia, Liliana
- Cats, Annemieke
- Gilbert, Duncan C
- Koerber, Stefan A
- Mai, Sabine
- Meulendijks, Didier
- Rödel, Franz
- Yhim, Ho-Young
- Hetjens, Svetlana
- Weiß, Christel
- Rasmussen, Christina L
- Urbute, Aivara
- Verdoodt, Freija
- Kjaer, Susanne K
- Reuschenbach, Miriam
- Goetghebeur, Els
- von Knebel Doeberitz, Magnus
- Arbyn, Marc
- Prigge, Elena-Sophie
DOIAbstract
High-risk human papillomavirus (hrHPV) types represent the aetiological agents in a major proportion of anal squamous cell carcinomas (ASCC). Several studies have suggested a prognostic relevance of HPV-related markers, particularly hrHPV DNA and p16INK4a (p16) protein expression, in patients with ASCC. However, broader evaluation of these prognostic marker candidates has been hampered by small cohort sizes and heterogeneous survival data among the individual studies. We conducted an individual patient data (IPD) meta-analysis to determine the prognostic value of hrHPV DNA and p16 in patients with ASCC while controlling for major clinical and tumour covariates
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