XBP1 is part of the ER stress response, and when activated in cancer cells, it fosters tumor growth. In this issue of Cell, Cubillos-Ruiz et al. demonstrate that XBP1 in tumor-infiltrating dendritic cells blunts anti-tumor immunity. These findings further imply XBP1 as a relevant target for cancer therapy
[[abstract]]Endoplasmic reticulum (ER) stress-activated unfolded protein response (UPR) plays multip...
Multiple physiological and pathological conditions interfere with the function of the endoplasmic re...
The endoplasmic reticulum (ER) is at the center of a number of vital cellular processes such as cell...
XBP1 is part of the ER stress response, and when activated in cancer cells, it fosters tumor growth....
SummaryDendritic cells (DCs) are required to initiate and sustain T cell-dependent anti-cancer immun...
Tumor-infiltrating myeloid cells, macrophages, and dendritic cells (DCs) are key regulators of tumor...
Dendritic cells (DCs) play a critical role in the initiation, maintenance, and resolution of an immu...
Tumor-infiltrating myeloid cells, such as dendritic cells (BMDC), are key regulators of tumor growth...
Metabolic, infectious and tumor cell-intrinsic noxae can all evoke the endoplasmic reticulum (ER) st...
Tumor-infiltrating myeloid cells, such as dendritic cells (BMDC), are key regulators of tumor growth...
Increased protein translation in cells and various factors in the tumor microenvironment can induce ...
Abstract Established tumors build a stressful and hostile microenvironment that block...
The tumor microenvironment is harbor to a variety of insults that privilege tumor cells to co-opt ho...
Tumor-associated macrophages (TAMs) display pro-tumorigenic phenotypes for supporting tumor progress...
Disturbance in the folding capacity of the endoplasmic reticulum (ER), caused by a variety of endoge...
[[abstract]]Endoplasmic reticulum (ER) stress-activated unfolded protein response (UPR) plays multip...
Multiple physiological and pathological conditions interfere with the function of the endoplasmic re...
The endoplasmic reticulum (ER) is at the center of a number of vital cellular processes such as cell...
XBP1 is part of the ER stress response, and when activated in cancer cells, it fosters tumor growth....
SummaryDendritic cells (DCs) are required to initiate and sustain T cell-dependent anti-cancer immun...
Tumor-infiltrating myeloid cells, macrophages, and dendritic cells (DCs) are key regulators of tumor...
Dendritic cells (DCs) play a critical role in the initiation, maintenance, and resolution of an immu...
Tumor-infiltrating myeloid cells, such as dendritic cells (BMDC), are key regulators of tumor growth...
Metabolic, infectious and tumor cell-intrinsic noxae can all evoke the endoplasmic reticulum (ER) st...
Tumor-infiltrating myeloid cells, such as dendritic cells (BMDC), are key regulators of tumor growth...
Increased protein translation in cells and various factors in the tumor microenvironment can induce ...
Abstract Established tumors build a stressful and hostile microenvironment that block...
The tumor microenvironment is harbor to a variety of insults that privilege tumor cells to co-opt ho...
Tumor-associated macrophages (TAMs) display pro-tumorigenic phenotypes for supporting tumor progress...
Disturbance in the folding capacity of the endoplasmic reticulum (ER), caused by a variety of endoge...
[[abstract]]Endoplasmic reticulum (ER) stress-activated unfolded protein response (UPR) plays multip...
Multiple physiological and pathological conditions interfere with the function of the endoplasmic re...
The endoplasmic reticulum (ER) is at the center of a number of vital cellular processes such as cell...
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