Hyperpolarized NMR Metabolomics at Natural 13 C Abundance

Analysis of Cancer Metabolism by Imaging Hyperpolarized Nuclei: Prospects for Translation to Clinical Research

Kurhanewicz, John
Vigneron, Daniel B.
Brindle, Kevin
Chekmenev, Eduard Y.
Comment, Arnaud
Cunningham, Charles H.
DeBerardinis, Ralph J.
Green, Gary G.
Leach, Martin O.
Rajan, Sunder S.
Rizi, Rahim R.
Ross, Brian D.
Warren, Warren S.
Malloy, Craig R.

February 2011

A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo with the ...

13C NMR Metabolomics: Applications at Natural Abundance

Clendinen, Chaevien S
Lee-McMullen, Brittany
Williams, Caroline M
Stupp, Gregory S
Vandenborne, Krista
Hahn, Daniel A
Walter, Glenn A
Edison, Arthur S

September 2014

(13)C NMR has many advantages for a metabolomics study, including a large spectral dispersion, narro...

Kinetics from Indirectly Detected Hyperpolarized NMR Spectroscopy by Using Spatially Selective Coherence Transfers

Harris, Talia
Giraudeau, Patrick
Frydman, Lucio

January 2011

An important recent development in NMR spectroscopy is the advent of ex situ dynamic nuclear polariz...

Hyperpolarized NMR Metabolomics at Natural 13 C Abundance

DEY, Arnab
CHARRIER, Benoit
MARTINEAU, Estelle
DEBORDE, Catherine
GANDRIAU, Elodie
MOING, Annick
JACOB, Daniel
ESHCHENKO, Dmitry
SCHNELL, Marc
MELZI, Roberto
KURZBACH, Dennis
CEILLIER, Morgan
CHAPPUIS, Quentin
COUSIN, Samuel
KEMPF, James
JANNIN, Sami
DUMEZ, Jean-Nicolas
GIRAUDEAU, Patrick

January 2020

Real-time diffusion NMR analysis of mixturessummitPersistent and Transportable Hyperpolarization for...

Diffusion MR of hyperpolarized 13 C molecules in solution

Koelsch, Bertram L
Keshari, Kayvan R
Peeters, Tom H
Larson, Peder EZ
Wilson, David M
Kurhanewicz, John

January 2013

We combined the high MR signal enhancement achieved using dissolution dynamic nuclear polarization (...

Hyperpolarized 1H and 13C NMR Spectroscopy in a Single Experiment for Metabolomics

Arnab Dey (1734139)
Benoît Charrier (1898338)
Victor Ribay (17372209)
Jean-Nicolas Dumez (1279860)
Patrick Giraudeau (1694341)

November 2023

The application of NMR spectroscopy to complex mixture analysis and, in particular, to metabolomics ...

Hyperpolarized NMR of plant and cancer cell extracts at natural abundance

Dumez, Jean-Nicolas
Milani, Jonas
Vuichoud, Basile
Bornet, Aurélien
Lalande-Martin, Julie
Téa, Illa
Yon, Maxime
Maucourt, Mickael
Deborde, Catherine
Moing, Annick
Frydman, Lucio
Bodenhausen, Geoffrey
Jannin, Sami
Giraudeau, Patrick

January 2015

International audienceNatural abundance C-13 NMR spectra of biological extracts are recorded in a si...

Pulsed magnetic resonance to signal‐enhance metabolites within seconds by utilizing para‐hydrogen.

Korchak, S.
Yang, S.
Mamone, S.
Glöggler, S.

May 2018

Diseases such as Alzheimer's and cancer have been linked to metabolic dysfunctions, and further unde...

Highly Repeatable Dissolution Dynamic Nuclear Polarization for Heteronuclear NMR Metabolomics

BORNET, Aurélien
MAUCOURT, Mickael
DEBORDE, Catherine
JACOB, Daniel
MILANI, Jonas
VUICHAUD, Basile
JI, Xiao
DUMEZ, Jean-Nicolas
MOING, Annick
BODENHAUSEN, Geoffrey
JANNIN, Sami
GIRAUDEAU, Patrick

June 2016

At natural C-13 abundance, metabolomics based on heteronuclear NMR is limited by sensitivity. We hav...

Separation of extra- and intracellular metabolites using hyperpolarized (13)C diffusion weighted MR.

Koelsch, Bertram L
Sriram, Renuka
Keshari, Kayvan R
Leon Swisher, Christine
Van Criekinge, Mark
Sukumar, Subramaniam
Vigneron, Daniel B
Wang, Zhen J
Larson, Peder EZ
Kurhanewicz, John

September 2016

This work demonstrates the separation of extra- and intracellular components of glycolytic metabolit...

Fine optimization of a dissolution dynamic nuclear polarization experimental setting for 13 C NMR of metabolic samples

Dey, Arnab
Charrier, Benoît
Lemaitre, Karine
Ribay, Victor
Eshchenko, Dmitry
Schnell, Marc
Melzi, Roberto
Stern, Quentin
Cousin, Samuel, F
Kempf, James, G
Jannin, Sami
Dumez, Jean-Nicolas
Giraudeau, Patrick

September 2022

International audienceNMR-based analysis of metabolite mixtures provides crucial information on biol...

Multidimensional NMR approaches towards highly resolved, sensitive and high-throughput quantitative metabolomics

Marchand, Jérémy
Martineau, Estelle
Guitton, Yann
Dervilly-Pinel, Gaud
Giraudeau, Patrick

January 2017

International audienceMulti-dimensional NMR is an appealing approach for dealing with the challengin...

Development of Diffusion Weighted Magnetic Resonance Acquisition Techniques for Hyperpolarized Carbon-13 Metabolites and Applications to Cancer Detection and Characterization

Koelsch, Bertram Lorenz

January 2014

Hyperpolarized carbon-13 magnetic resonance (MR) is a molecular imaging technique that allows for re...

Quantitative NMR spectroscopy applied to metabolism study using hyperpolarized 13C and to salt-matrix interactions in food

El Sabbagh, Nour

January 2022

L’imagerie spectroscopique par résonance magnétique des noyaux X, tel que le 13C, offre des spectres...

Improved Acquisition Methods for Hyperpolarized Carbon-13 Magnetic Resonance Imaging

Tang, Shuyu

January 2019

Magnetic resonance imaging with hyperpolarized 13C-labeled compounds via dynamic nuclear polarizatio...

Analysis of Cancer Metabolism by Imaging Hyperpolarized Nuclei: Prospects for Translation to Clinical Research

Kurhanewicz, John
Vigneron, Daniel B.
Brindle, Kevin
Chekmenev, Eduard Y.
Comment, Arnaud
Cunningham, Charles H.
DeBerardinis, Ralph J.
Green, Gary G.
Leach, Martin O.
Rajan, Sunder S.
Rizi, Rahim R.
Ross, Brian D.
Warren, Warren S.
Malloy, Craig R.

February 2011

A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo with the ...

13C NMR Metabolomics: Applications at Natural Abundance

Clendinen, Chaevien S
Lee-McMullen, Brittany
Williams, Caroline M
Stupp, Gregory S
Vandenborne, Krista
Hahn, Daniel A
Walter, Glenn A
Edison, Arthur S

September 2014

(13)C NMR has many advantages for a metabolomics study, including a large spectral dispersion, narro...

Kinetics from Indirectly Detected Hyperpolarized NMR Spectroscopy by Using Spatially Selective Coherence Transfers

Harris, Talia
Giraudeau, Patrick
Frydman, Lucio

January 2011

An important recent development in NMR spectroscopy is the advent of ex situ dynamic nuclear polariz...

Hyperpolarized NMR Metabolomics at Natural 13 C Abundance

DEY, Arnab
CHARRIER, Benoit
MARTINEAU, Estelle
DEBORDE, Catherine
GANDRIAU, Elodie
MOING, Annick
JACOB, Daniel
ESHCHENKO, Dmitry
SCHNELL, Marc
MELZI, Roberto
KURZBACH, Dennis
CEILLIER, Morgan
CHAPPUIS, Quentin
COUSIN, Samuel
KEMPF, James
JANNIN, Sami
DUMEZ, Jean-Nicolas
GIRAUDEAU, Patrick

January 2020

Real-time diffusion NMR analysis of mixturessummitPersistent and Transportable Hyperpolarization for...

Diffusion MR of hyperpolarized 13 C molecules in solution

Koelsch, Bertram L
Keshari, Kayvan R
Peeters, Tom H
Larson, Peder EZ
Wilson, David M
Kurhanewicz, John

January 2013

We combined the high MR signal enhancement achieved using dissolution dynamic nuclear polarization (...

Hyperpolarized 1H and 13C NMR Spectroscopy in a Single Experiment for Metabolomics

Arnab Dey (1734139)
Benoît Charrier (1898338)
Victor Ribay (17372209)
Jean-Nicolas Dumez (1279860)
Patrick Giraudeau (1694341)

November 2023

The application of NMR spectroscopy to complex mixture analysis and, in particular, to metabolomics ...

Hyperpolarized NMR of plant and cancer cell extracts at natural abundance

Dumez, Jean-Nicolas
Milani, Jonas
Vuichoud, Basile
Bornet, Aurélien
Lalande-Martin, Julie
Téa, Illa
Yon, Maxime
Maucourt, Mickael
Deborde, Catherine
Moing, Annick
Frydman, Lucio
Bodenhausen, Geoffrey
Jannin, Sami
Giraudeau, Patrick

January 2015

International audienceNatural abundance C-13 NMR spectra of biological extracts are recorded in a si...

Pulsed magnetic resonance to signal‐enhance metabolites within seconds by utilizing para‐hydrogen.

Korchak, S.
Yang, S.
Mamone, S.
Glöggler, S.

May 2018

Diseases such as Alzheimer's and cancer have been linked to metabolic dysfunctions, and further unde...

Highly Repeatable Dissolution Dynamic Nuclear Polarization for Heteronuclear NMR Metabolomics

BORNET, Aurélien
MAUCOURT, Mickael
DEBORDE, Catherine
JACOB, Daniel
MILANI, Jonas
VUICHAUD, Basile
JI, Xiao
DUMEZ, Jean-Nicolas
MOING, Annick
BODENHAUSEN, Geoffrey
JANNIN, Sami
GIRAUDEAU, Patrick

June 2016

At natural C-13 abundance, metabolomics based on heteronuclear NMR is limited by sensitivity. We hav...

Separation of extra- and intracellular metabolites using hyperpolarized (13)C diffusion weighted MR.

Koelsch, Bertram L
Sriram, Renuka
Keshari, Kayvan R
Leon Swisher, Christine
Van Criekinge, Mark
Sukumar, Subramaniam
Vigneron, Daniel B
Wang, Zhen J
Larson, Peder EZ
Kurhanewicz, John

September 2016

This work demonstrates the separation of extra- and intracellular components of glycolytic metabolit...

Fine optimization of a dissolution dynamic nuclear polarization experimental setting for 13 C NMR of metabolic samples

Dey, Arnab
Charrier, Benoît
Lemaitre, Karine
Ribay, Victor
Eshchenko, Dmitry
Schnell, Marc
Melzi, Roberto
Stern, Quentin
Cousin, Samuel, F
Kempf, James, G
Jannin, Sami
Dumez, Jean-Nicolas
Giraudeau, Patrick

September 2022

International audienceNMR-based analysis of metabolite mixtures provides crucial information on biol...

Multidimensional NMR approaches towards highly resolved, sensitive and high-throughput quantitative metabolomics

Marchand, Jérémy
Martineau, Estelle
Guitton, Yann
Dervilly-Pinel, Gaud
Giraudeau, Patrick

January 2017

International audienceMulti-dimensional NMR is an appealing approach for dealing with the challengin...

Development of Diffusion Weighted Magnetic Resonance Acquisition Techniques for Hyperpolarized Carbon-13 Metabolites and Applications to Cancer Detection and Characterization

Koelsch, Bertram Lorenz

January 2014

Hyperpolarized carbon-13 magnetic resonance (MR) is a molecular imaging technique that allows for re...

Quantitative NMR spectroscopy applied to metabolism study using hyperpolarized 13C and to salt-matrix interactions in food

El Sabbagh, Nour

January 2022

L’imagerie spectroscopique par résonance magnétique des noyaux X, tel que le 13C, offre des spectres...

Improved Acquisition Methods for Hyperpolarized Carbon-13 Magnetic Resonance Imaging

Tang, Shuyu

January 2019

Magnetic resonance imaging with hyperpolarized 13C-labeled compounds via dynamic nuclear polarizatio...

Analysis of Cancer Metabolism by Imaging Hyperpolarized Nuclei: Prospects for Translation to Clinical Research

Kurhanewicz, John
Vigneron, Daniel B.
Brindle, Kevin
Chekmenev, Eduard Y.
Comment, Arnaud
Cunningham, Charles H.
DeBerardinis, Ralph J.
Green, Gary G.
Leach, Martin O.
Rajan, Sunder S.
Rizi, Rahim R.
Ross, Brian D.
Warren, Warren S.
Malloy, Craig R.

February 2011

A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo with the ...

13C NMR Metabolomics: Applications at Natural Abundance

Clendinen, Chaevien S
Lee-McMullen, Brittany
Williams, Caroline M
Stupp, Gregory S
Vandenborne, Krista
Hahn, Daniel A
Walter, Glenn A
Edison, Arthur S

September 2014

(13)C NMR has many advantages for a metabolomics study, including a large spectral dispersion, narro...

Kinetics from Indirectly Detected Hyperpolarized NMR Spectroscopy by Using Spatially Selective Coherence Transfers

Harris, Talia
Giraudeau, Patrick
Frydman, Lucio

January 2011

An important recent development in NMR spectroscopy is the advent of ex situ dynamic nuclear polariz...

Hyperpolarized NMR Metabolomics at Natural 13 C Abundance

Abstract

Extracted data

Hyperpolarized NMR Metabolomics at Natural 13 C Abundance

Abstract

Extracted data

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