Celiac Disease

Celiac disease is chronic autoimmune-mediated small intestinal enteropathy. CD caused by ingestion of the dietary gluten that found in wheat, barley, and rye, in the individual who are predisposed genetically by having leucocyte antigen, (HLA)-DQ2 or -DQ8-positive. Rigorous adherence to a gluten-free diet is the only treatment for this condition to reduce the symptoms and the consequences at the short-term and the long term. The aim of this chapter is provide updates and comprehensive overview about the celiac disease epidemiology, pathogenetic information, clinical, and diagnostic methods, updated therapeutic strategy approaches that followed as a treatment and recommendations. Its challenge to understand all the domains that causes celiac disease. Finding alternative diet and trying different lifestyle still under debates. However, complete exclusion of the gluten-containing food from the patient’s diet is the only effective treatment to avoid the disease complications