Severe bronchiolitis profiles and risk of asthma development in Finnish children
- Dumas, Orianne
- Erkkola, Riku
- Bergroth, Eija
- Hasegawa, Kohei
- Mansbach, Jonathan,
- Piedra, Pedro,
- Jartti, Tuomas
- Camargo, Carlos,
DOIAbstract
International audienceBackground: Recent studies support the existence of several entities under the clinical diagnosis of "bronchiolitis". Among infants with severe bronchiolitis, distinct profiles have been differentially associated with development of recurrent wheezing by age 3 years. However, their associations with actual asthma remain unclear.Objectives: To study the association between severe bronchiolitis profiles identified by a clustering approach and childhood asthma.Methods: Among 408 children (age <2 years) hospitalized with bronchiolitis in Finland (2008-2010), latent class analysis identified three bronchiolitis profiles: profile A (47%), characterized by history of wheezing/eczema, wheezing during acute illness and rhinovir...
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