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Not AvailableVirus-resistant transgenic plants form an essential constituent of crop protection measures. Tomato is an important vegetable crop grown throughout the world for its nutritional benefits and tomatobased processed food consumption. However, the production levels of tomato are threatened by many viral infections. In the absence of resistant tomato genotypes (where available genetic sources or resistance are scarce), development of transgenic resistance to pathogenic viruses is indispensable. The last couple of decades have witnessed substantial progress in incorporating virus resistance trait in tomato. This chapter provides overview of the strategies and successful instances of transgenic virus resistance with special emphasis on prominent viruses infecting tomato. Various approaches to incorporate virus resistance in tomato from antisense RNA expression, through various RNA interference (RNAi) based strategies and foray in to genome editing techniques are discussed. The significant achievements made in developing transgenic resistance to combat Tomato leaf curl viruses, ground nut bud necrosis virus and Cucumber mosaic virus are presented. Also, the utility of employing recently emerging genome editing tool in incorporating resistance to tomato viruses is also discussed.Not Availabl