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Not AvailableHealthy shrimp culture system is always in harmony with the ecology of the pond environment. This can be manipulated by developing a dense heterotrophic bacterial community that takes care of waste generated in the system through in situ bioremediation. Considering the importance to reduce an occurrence of luminous vibriosis in shrimp aquaculture, countless studies have been carried out with an objective to screen anti-vibrio biological agents, which can be used as an alternative to antibiotics. In such studies, microalgae, bacteriophage, and probiotic bacteria have been found to have potential benefits in reducing vibriosis. Eco-based shrimp farming, green water technology, bio-floc technology, phage therapy, and integrated multi-trophic aquaculture (IMTA), since their inception, hold a promising alternative to antibiotics in the near future. This article seeks to secure all the available information on different biological agents, their involvement in lowering Vibrio load, and strategies to control Vibrio infection in shrimp aquaculture.Not Availabl