Wilson’s Disease Presenting with Generalized Tonic-Clonic Seizure and Cerebellar Dysfunction

Aziz Rahman Rasib,1 Aemal Aziz Jabarkhil,1 Mohammad Faiq Sediqi,2,3 Ahmad Irshad Mansoor,1,4 Abdullah Asady5 1Department of Neuropsychiatry, Kabul University of Medical Sciences, Kabul, 1001, Afghanistan; 2Department of Histology, Kabul University of Medical Sciences, Kabul, 1001, Afghanistan; 3Department of Basic Medical Sciences, International Islamic University Malaysia, Kuantan, 25200, Malaysia; 4Division of Psychology & Systems Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London and London School of Hygiene and Tropical Medicine, London, UK; 5Department of Microbiology, Kabul University of Medical Sciences, Kabul, 1001, AfghanistanCorrespondence: Aziz Rahman RasibDepartment of Neuropsychiatry, Kabul University of Medical Sciences, Kabul, 1001, AfghanistanTel +93 797089250Email azizrahmanrasib@gmail.comAbstract: Wilson’s disease (WD) is a rare inherited impaired copper metabolism with diverse clinical pictures dominated by hepatic and neurologic manifestations. We report the case of a 14-year-old female patient who attended the Department of Neuropsychiatry at Ali Abad Teaching Hospital, Kabul, Afghanistan, with generalized tonic-clonic seizure and cerebellar dysfunction. The patient was initially diagnosed as encephalitis and epilepsy and finally diagnosed with WD based on the clinical and laboratory findings. After 6 months of follow-up, the patient showed substantial clinical recovery.Keywords: Wilson’s disease, copper accumulation, KF rings, seizure, cerebellar dysfunctio