Androgen replacement therapy for cancer‐related symptoms in male: result of prospective randomized trial (ARTFORM study)
- Kouji Izumi
- Hiroaki Iwamoto
- Hiroshi Yaegashi
- Takahiro Nohara
- Kazuyoshi Shigehara
- Yoshifumi Kadono
- Shigeki Nanjo
- Tadaaki Yamada
- Koshiro Ohtsubo
- Seiji Yano
- Atsushi Mizokami
DOIAbstract
Abstract Background Hypogonadism associated with cancer is reported to cause cachexia and a variety of physical and psychological symptoms. This study aims to evaluate whether androgen replacement therapy can improve cancer‐related symptoms in male advanced cancer patients. Methods An investigator‐initiated, prospective, and randomized controlled study was conducted. Patients with low serum testosterone levels (total or free testosterone levels were <2.31 ng/mL or <11.8 pg/mL, respectively) were randomly assigned to the control or testosterone enanthate administration (testosterone group) groups. Testosterone enanthate was injected into the muscle tissue at a dose of 250 mg every 4 weeks (baseline, week 4, and week 8). Differences in qualit...
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