LncRNA MORT (ZNF667-AS1) in cancer — is there a possible role in gynecological malignancies?
- Fiore, Riccardo Di
- Suleiman, Sherif
- Drago-Ferrante, Rosa
- Felix, Ana
- O’Toole, Sharon A.
- O’Leary, John J.
- Ward, Mark P.
- Beirne, James P.
- Yordanov, Angel
- Vasileva-Slaveva, Mariela
- Subbannayya, Yashwanth
- Pentimalli, Francesca
- Giordano, Antonio
- Calleja-Agius, Jean
DOIAbstract
Gynecological cancers (GCs) are currently among the major threats to female health. Moreover, there are different histologic subtypes of these cancers, which are defined as ‘rare’ due to an annual incidence of <6 per 100,000 women. The majority of these tend to be associated with a poor prognosis. Long non-coding RNAs (lncRNAs) play a critical role in the normal development of organisms as well as in tumorigenesis. LncRNAs can be classified into tumor suppressor genes or oncogenes, depending on their function within the cellular context and the signaling pathways in which they are involved. These regulatory RNAs are potential therapeutic targets for cancer due to their tissue and tumor specificity. However, there still needs to be a ...
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