Add to ORKGThe human pluripotent leukemia cell line, K562, spontaneously produces variable quantities of Hb Gower I (=ε2ζ2) and Hb Bart's (=γ4). The Hb production of K562 cells is stimulated by hemin and some other compounds. The possibility of manipulating the production of different hemoglobins is of great interest because it might help to identify biochemical mechanisms which could regulate the switching of embryonic to fetal to adult Hb biosynthesis. However, K562 cells demonstrate a great variability in the quantities and types of Hb produced in response to hemin.peer-reviewe
This research was originally published in Blood. BECKER, A. J., MCCULLOC.EA, SIMINOVI.L, & TILL, J. ...
Chronic myeloid leukemia (CML) results from a chromosomal abnormality that leads to uncontrolled div...
What causes the gradual decrease of fetal he-moglobin in the normal maturing infant, or the persiste...
K562 is a pluripotent human leukemia cell line that spontaneously produces variable numbers of hemog...
The human leukemia K562 cell line can be induced by 20 M hemin to reversibly accumulate embryonic an...
Long-term cultures of K562(S) cells in 50-75 microM hemin allow the selection of 'hemin-resistant' K...
We have studied the expression of the c-myc and c-abl oncogenes in two human leukemic K562 cell line...
The concept that has emerged from our experiments and those of others is that erythroid stem cells a...
Two sublines of the human leukemia cell line K562 including the original cell line and three clones ...
Induction of fetal hemoglobin (HbF) is considered a promising strategy in the treatment of b-thalas...
This study investigated whether relative changes that accompany the naturally occurring shifts in ha...
The human leukaemic K562 cell line can be induced in vitro to undergo erythroid differentiation by a...
We have previously shown that coculture of human embryonic stem cells (hESCs) for 14 days with immor...
<div><p>Decades of research have established that the most effective treatment for sickle cell disea...
In addition to the difficulties caused by in-creased hemolysis of peripheral red cells, patients wit...
This research was originally published in Blood. BECKER, A. J., MCCULLOC.EA, SIMINOVI.L, & TILL, J. ...
Chronic myeloid leukemia (CML) results from a chromosomal abnormality that leads to uncontrolled div...
What causes the gradual decrease of fetal he-moglobin in the normal maturing infant, or the persiste...
K562 is a pluripotent human leukemia cell line that spontaneously produces variable numbers of hemog...
The human leukemia K562 cell line can be induced by 20 M hemin to reversibly accumulate embryonic an...
Long-term cultures of K562(S) cells in 50-75 microM hemin allow the selection of 'hemin-resistant' K...
We have studied the expression of the c-myc and c-abl oncogenes in two human leukemic K562 cell line...
The concept that has emerged from our experiments and those of others is that erythroid stem cells a...
Two sublines of the human leukemia cell line K562 including the original cell line and three clones ...
Induction of fetal hemoglobin (HbF) is considered a promising strategy in the treatment of b-thalas...
This study investigated whether relative changes that accompany the naturally occurring shifts in ha...
The human leukaemic K562 cell line can be induced in vitro to undergo erythroid differentiation by a...
We have previously shown that coculture of human embryonic stem cells (hESCs) for 14 days with immor...
<div><p>Decades of research have established that the most effective treatment for sickle cell disea...
In addition to the difficulties caused by in-creased hemolysis of peripheral red cells, patients wit...
This research was originally published in Blood. BECKER, A. J., MCCULLOC.EA, SIMINOVI.L, & TILL, J. ...
Chronic myeloid leukemia (CML) results from a chromosomal abnormality that leads to uncontrolled div...
What causes the gradual decrease of fetal he-moglobin in the normal maturing infant, or the persiste...