Glycodendron microarrays with defined valency have been constructed by on-chip synthesis on hydrophobic indium tin oxide (ITO) coated glass slides and employed in lectin–carbohydrate binding studies with several plant and human lectins. Glycodendrons presenting sugar epitopes at different valencies were prepared by spotwise strain-promoted azide–alkyne cycloaddition (SPAAC) between immobilised cyclooctyne dendrons and azide functionalised glycans. The non-covalent immobilisation of dendrons on the ITO surface by hydrophobic interaction allowed us to study dendron surface density and SPAAC conversion rate by in situ MALDI-TOF MS analysis. By diluting the dendron surface density we could study how the carbohydrate–lectin interactions became e...
Carbohydrate and protein interactions are often essential in viral and bacterial infection, the immu...
New technologies based on microarray methods have begun to feature widely in carbohydrate chemistry ...
ABSTRACT: Interactions of mucin glycoproteins with cognate receptors are dictated by the structures ...
International audienceGlycodendron microarrays with defined valency have been constructed by on-chip...
Glycan microarrays are a versatile tool for the identification of endogenous ligands and effective i...
Multivalent ligand–protein interactions are a commonly employed approach by nature in many biologica...
Carbohydrate-\u200blectin interactions play an important role in the immune system with functions in...
Glycans, and the proteins that recognize them, are involved in numerous functions throughout an orga...
International audienceCarbohydrate−protein interactions play key roles in a wide variety of biologic...
Microarray technologies inspired the development of carbohydrate arrays. Initially, carbohydrate arr...
AbstractThis paper reports a chemical strategy for preparing carbohydrate arrays and utilizes these ...
We report a new type of microarray, based on glyconanoparticles (GNPs), to study glycan–lectin inter...
Multivalency is an important phenomenon in protein–carbohydrate interactions. In order to evaluate g...
Glycan microarray has become a powerful high-throughput tool for examining binding interactions of c...
Glycan microarrays are an increasingly utilised tool for analysis of protein-carbohydrate interactio...
Carbohydrate and protein interactions are often essential in viral and bacterial infection, the immu...
New technologies based on microarray methods have begun to feature widely in carbohydrate chemistry ...
ABSTRACT: Interactions of mucin glycoproteins with cognate receptors are dictated by the structures ...
International audienceGlycodendron microarrays with defined valency have been constructed by on-chip...
Glycan microarrays are a versatile tool for the identification of endogenous ligands and effective i...
Multivalent ligand–protein interactions are a commonly employed approach by nature in many biologica...
Carbohydrate-\u200blectin interactions play an important role in the immune system with functions in...
Glycans, and the proteins that recognize them, are involved in numerous functions throughout an orga...
International audienceCarbohydrate−protein interactions play key roles in a wide variety of biologic...
Microarray technologies inspired the development of carbohydrate arrays. Initially, carbohydrate arr...
AbstractThis paper reports a chemical strategy for preparing carbohydrate arrays and utilizes these ...
We report a new type of microarray, based on glyconanoparticles (GNPs), to study glycan–lectin inter...
Multivalency is an important phenomenon in protein–carbohydrate interactions. In order to evaluate g...
Glycan microarray has become a powerful high-throughput tool for examining binding interactions of c...
Glycan microarrays are an increasingly utilised tool for analysis of protein-carbohydrate interactio...
Carbohydrate and protein interactions are often essential in viral and bacterial infection, the immu...
New technologies based on microarray methods have begun to feature widely in carbohydrate chemistry ...
ABSTRACT: Interactions of mucin glycoproteins with cognate receptors are dictated by the structures ...