SUMO belongs to the ubiquitin-like family (UbL) of protein modifiers. SUMO is conserved among eukaryotes and is essential for the regulation of processes such as DNA damage repair, transcription, DNA replication and mitosis. UbL modification of proteins occurs via a specific enzymatic cascade formed by the crosstalk between the E1-activating enzyme, the E2-conjugating enzyme and the E3-ligase. An essential discrimination step in all UbL modifiers corresponds to the interaction between E1 and E2 enzymes, which is mediated by the recruitment of the E2 to the UFD domain (Ubiquitin-Fold Domain) of the E1 enzyme. To gain insights in the properties of this interface, we have compared the structures of the complexes between E1 UFD domain and E2 in...
AbstractSUMO is covalently linked to a variety of cellular proteins. Three groups now describe relat...
AbstractCovalent posttranslational modification with SUMO (small ubiquitin-related modifier) modulat...
La ubiquitinació i la SUMOilació són dos de les modificacions post-traduccionals més estudiades (PTM...
SUMO belongs to the ubiquitin-like family (UbL) of protein modifiers. SUMO is conserved among eukary...
SUMO belongs to the ubiquitin-like family (UbL) of protein modifiers. SUMO is conserved among eukary...
Canonical ubiquitin-like proteins (UBLs) such as ubiquitin, Sumo, NEDD8, and ISG15 are ligated to ta...
AbstractE2 enzymes catalyze attachment of ubiquitin and ubiquitin-like proteins to lysine residues d...
The ubiquitin-like proteins (Ubls) are small polypeptides that function as post-translational modifi...
Posttranslational modification of macromolecules by ubiquitin-like proteins (UBLs) such as ubiquitin...
AbstractE2 enzymes catalyze attachment of ubiquitin and ubiquitin-like proteins to lysine residues d...
SUMO (small ubiquitin-like modifier) emerged from the shadow of the well-established ubiquitin some ...
SUMO (small ubiquitin-like modifier) emerged from the shadow of the well-established ubiquitin some ...
SUMO (small ubiquitin-like modifier) emerged from the shadow of the well-established ubiquitin some ...
E3 protein ligases enhance transfer of ubiquitin-like (Ubl) proteins from E2 conjugating enzymes to ...
Small ubiquitin-related modifier (SUMO) is a member of the ubiquitin-related protein family. SUMO mo...
AbstractSUMO is covalently linked to a variety of cellular proteins. Three groups now describe relat...
AbstractCovalent posttranslational modification with SUMO (small ubiquitin-related modifier) modulat...
La ubiquitinació i la SUMOilació són dos de les modificacions post-traduccionals més estudiades (PTM...
SUMO belongs to the ubiquitin-like family (UbL) of protein modifiers. SUMO is conserved among eukary...
SUMO belongs to the ubiquitin-like family (UbL) of protein modifiers. SUMO is conserved among eukary...
Canonical ubiquitin-like proteins (UBLs) such as ubiquitin, Sumo, NEDD8, and ISG15 are ligated to ta...
AbstractE2 enzymes catalyze attachment of ubiquitin and ubiquitin-like proteins to lysine residues d...
The ubiquitin-like proteins (Ubls) are small polypeptides that function as post-translational modifi...
Posttranslational modification of macromolecules by ubiquitin-like proteins (UBLs) such as ubiquitin...
AbstractE2 enzymes catalyze attachment of ubiquitin and ubiquitin-like proteins to lysine residues d...
SUMO (small ubiquitin-like modifier) emerged from the shadow of the well-established ubiquitin some ...
SUMO (small ubiquitin-like modifier) emerged from the shadow of the well-established ubiquitin some ...
SUMO (small ubiquitin-like modifier) emerged from the shadow of the well-established ubiquitin some ...
E3 protein ligases enhance transfer of ubiquitin-like (Ubl) proteins from E2 conjugating enzymes to ...
Small ubiquitin-related modifier (SUMO) is a member of the ubiquitin-related protein family. SUMO mo...
AbstractSUMO is covalently linked to a variety of cellular proteins. Three groups now describe relat...
AbstractCovalent posttranslational modification with SUMO (small ubiquitin-related modifier) modulat...
La ubiquitinació i la SUMOilació són dos de les modificacions post-traduccionals més estudiades (PTM...