Functional plasmidomics

Trabajo presentado en Mikrobiogune, celebrado en Bilbao (España) el 11 de diciembre de 2018.The Intergenomics group is interested in several aspects of the horizontal gene transfer mediated by plasmids. Some of our current research lines deal with the natural and artificial strategies to control plasmid spread through conjugation, the transcriptional regulatory networks of conjugative plasmids, plasmid ecology, and the engineering of synthetic biology circuits for distributed bacterial computations using plasmids as communication devices. We have developed some bioinformatics tools to: i) reconstruct plasmid sequences from Illumina data (PLACNET), ii) analyze plasmid mobility (MOBscan), and iii) perform comparative plasmid genomics (AcCNET and pANI)