10 pags, 1 fig.The understanding of the complex conformational landscape of amyloid aggregation and its modulation by relevant physicochemical and cellular factors is a prerequisite for elucidating some of the molecular basis of pathology in amyloid related diseases, and for developing and evaluating effective disease-specific therapeutics to reduce or eliminate the underlying sources of toxicity in these diseases. Interactions of proteins with solvating water have been long considered to be fundamental in mediating their function and folding; however, the relevance of water in the process of protein amyloid aggregation has been largely overlooked. Here, we provide a perspective on the role water plays in triggering primary amyloid nucleati...
The aqueous environment is a pervasive factor which, in many ways, determines the protein folding pr...
Hydration water is vital for various macromolecular biological activities, such as specific ligand r...
Protein folding/misfolding in vivo takes place in a highly crowded and confined environment. Such cr...
The understanding of the complex conformational landscape of amyloid aggregation and its modulation ...
The understanding of the complex conformational landscape of amyloid aggregation and its modulation ...
The understanding of the complex conformational landscape of amyloid aggregation and its modulation ...
The essential involvement of water in most fundamental extra-cellular and intracellular processes of...
A variety of neurodegenerative diseases are associated with amyloid plaques, which begin as soluble ...
a-Synuclein amyloid self-assembly is the hallmark of a number of neurodegenerative disorders, includ...
13 pags., 8 figs.α-Synuclein amyloid self-assembly is the hallmark of a number of neurodegenerative ...
The essential involvement of water in most fundamental extra-cellular and intracellular processes of...
A variety of neurodegenerative diseases are associated with amyloid plaques, which begin as soluble ...
Abstract: The crucial role of water in amyloid-β(Aβ) fibril proteins is evaluated in several ways i...
Water plays a critical role in governing the intricate balance between chain-chain and chain-solvent...
The aqueous environment is a pervasive factor which, in many ways, determines the protein folding pr...
The aqueous environment is a pervasive factor which, in many ways, determines the protein folding pr...
Hydration water is vital for various macromolecular biological activities, such as specific ligand r...
Protein folding/misfolding in vivo takes place in a highly crowded and confined environment. Such cr...
The understanding of the complex conformational landscape of amyloid aggregation and its modulation ...
The understanding of the complex conformational landscape of amyloid aggregation and its modulation ...
The understanding of the complex conformational landscape of amyloid aggregation and its modulation ...
The essential involvement of water in most fundamental extra-cellular and intracellular processes of...
A variety of neurodegenerative diseases are associated with amyloid plaques, which begin as soluble ...
a-Synuclein amyloid self-assembly is the hallmark of a number of neurodegenerative disorders, includ...
13 pags., 8 figs.α-Synuclein amyloid self-assembly is the hallmark of a number of neurodegenerative ...
The essential involvement of water in most fundamental extra-cellular and intracellular processes of...
A variety of neurodegenerative diseases are associated with amyloid plaques, which begin as soluble ...
Abstract: The crucial role of water in amyloid-β(Aβ) fibril proteins is evaluated in several ways i...
Water plays a critical role in governing the intricate balance between chain-chain and chain-solvent...
The aqueous environment is a pervasive factor which, in many ways, determines the protein folding pr...
The aqueous environment is a pervasive factor which, in many ways, determines the protein folding pr...
Hydration water is vital for various macromolecular biological activities, such as specific ligand r...
Protein folding/misfolding in vivo takes place in a highly crowded and confined environment. Such cr...