Add to ORKGThe invention relates to a method to predict the response to treatment with radiotherapy combined with cisplatin-based chemotherapy in patients with cancer, preferably non-microcytic lung cancer, wherein said method is based on the detection of the presence of methylation in the IGFBP-3 gene. The present invention also relates to an in vitro method to design a customised treatment for an individual with said disease. The method of the invention may be quantitative or semi-quantitative. The present invention also relates to a probe designed for the quantitative detection of the methylation of the IGFBP-3 gene, to a kit that comprises it and to the use of the kit to predict the response of a subject to the aforementioned treatmentPeer reviewe...
Lung cancer has the leading mortality rate among all cancer types and is the second most common caus...
The invention relates to a method of determining whether a human subject is suffering from or at ris...
Aberrant hypermethylation of promoter regions in specific genes is a key event in the formation and ...
The invention relates to a method to predict the response to treatment with radiotherapy combined wi...
The invention relates to a method for predicting the response to treatment with radiotherapy combine...
et al.Although many cancers initially respond to cisplatin (CDDP)-based chemotherapy, resistance fre...
DNA methylation is an epigenetic process that has roles in many normal cellular processes and dysreg...
A method for quantifying the methylated allele of 06-methylguanine-DNA methyltransferase (MGMT) prom...
[ES] Determinación de la metilación y niveles de un miARN en respuesta a un compuesto antitumoral ba...
O-6-methylguanine-DNA methyltransferase (MGMT) has been associated with resistance to alkylating age...
Epigenetic silencing of the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) by pr...
Many studies have been performed to assess the development and application of potentially useful tec...
DNA methylation, which is an important epigenetic event for transcriptional regulation, is regarded ...
Methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to th...
BACKGROUND: IGFBP-3 is a multifunctional protein that inhibits growth and induces apoptosis of cance...
Lung cancer has the leading mortality rate among all cancer types and is the second most common caus...
The invention relates to a method of determining whether a human subject is suffering from or at ris...
Aberrant hypermethylation of promoter regions in specific genes is a key event in the formation and ...
The invention relates to a method to predict the response to treatment with radiotherapy combined wi...
The invention relates to a method for predicting the response to treatment with radiotherapy combine...
et al.Although many cancers initially respond to cisplatin (CDDP)-based chemotherapy, resistance fre...
DNA methylation is an epigenetic process that has roles in many normal cellular processes and dysreg...
A method for quantifying the methylated allele of 06-methylguanine-DNA methyltransferase (MGMT) prom...
[ES] Determinación de la metilación y niveles de un miARN en respuesta a un compuesto antitumoral ba...
O-6-methylguanine-DNA methyltransferase (MGMT) has been associated with resistance to alkylating age...
Epigenetic silencing of the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) by pr...
Many studies have been performed to assess the development and application of potentially useful tec...
DNA methylation, which is an important epigenetic event for transcriptional regulation, is regarded ...
Methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to th...
BACKGROUND: IGFBP-3 is a multifunctional protein that inhibits growth and induces apoptosis of cance...
Lung cancer has the leading mortality rate among all cancer types and is the second most common caus...
The invention relates to a method of determining whether a human subject is suffering from or at ris...
Aberrant hypermethylation of promoter regions in specific genes is a key event in the formation and ...